›› 1997, Vol. 15 ›› Issue (5): 292-296.

• 论著 • Previous Articles     Next Articles

IN VITRO SENSITIVITY OF PLASMODIUM FALCIPARUM TO DERIVATIVESOF ARTEMISININ, PYRONARIDINE AND CHLOROQUINE IN YUNNAN

Yang Henglin1; Liu Dequan2; Huang Kaiguo1; Dong Ying1; Yang Yaming1; Yang
Pinfang1; L iao Mingzheng3; Zhang Chunyong2; Liu Ruijun2   

  1. 1 Institute of Malaria Prevention and Treatmentof Yunnan Province; Simao665000 2　Institute of Parasistic Diseases, Chinese Academy of Preventive Medicine, Shanghai 2000253　Ruili City Antiepidemic Station, Ruili 678600
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-10-30 Published:1997-10-30

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Abstract: AIM:To examine the sensitivity of Plasmodium falciparum to six antimalarials in
south Yunnan in 1991—1993.METHODS:Rieckmanns in vitro microtechnique was used.The responses of P.falciparum to chloroquine,pyronaridine and derivatives of artemisinin including artesunate, dihydroartemisinin,arteether and artemether were assayed. RESULTS:The resistance rates
of P.falciparum from southeast,west and south Yunnan,Laos,Myrnmar were 79%— 96 % ,and ID50 were
122— 240 nmol/L to chloroquine; whereas the resistance rates were 20% —35% , and ID50 were 16—32 nmol/L to pyronaridine. The resistance rates were 5% —16% to the derivatives of artemisinin, while P.falciparum from Laos showed high sensitivity to the derivatives of artemisinin. CONCLUSION: The resistance of P. falciparum to chloroquine were popular in Yunnan, most of the isolates were sensitive to the above-mentioned derivatives of artemisinin and pyronaridine, only a few isolates exhibited
resistance.

Key words: Plasmodium falciparum, in vitro test, derivatives of artem isinin, pyronaridine, chloroquine