多房棘球蚴对宿主肝细胞损害机制的研究进展

doi:10.12140/j.issn.1000-7423.2021.02.020

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (2): 256-259.doi: 10.12140/j.issn.1000-7423.2021.02.020

多房棘球蚴对宿主肝细胞损害机制的研究进展

徐凯¹^,²(), 王海久¹^,², 张丽¹, 张耀刚², 樊海宁¹^,², 任利¹, 任宾¹, 王志鑫¹^,²^,^*()

1 青海大学附属医院肝胆胰外科,西宁 810001
2 青海省包虫病研究重点实验室,西宁 810001

收稿日期:2020-06-11 修回日期:2020-10-24 出版日期:2021-04-30 发布日期:2021-04-30
通讯作者: 王志鑫
作者简介:徐凯（1992-）,男,硕士研究生,从事棘球蚴病基础研究。E-mail： 348890863@qq.com
基金资助:
第二批青海省“高端创新人才千人计划”项目（培养拔尖人才）;中科院“西部之光”（青年学者）项目;青海大学附属医院中青年科研基金重点项目(ASRF-2016-01)

Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis

XU Kai¹^,²(), WANG Hai-jiu¹^,², ZHANG Li¹, ZHANG Yao-gang², FAN Hai-ning¹^,², REN Li¹, REN Bin¹, WANG Zhi-xin¹^,²^,^*()

1 Department of Hepatopancreatobiliary Surgery, the Affiliated Hospital of Qinghai University, Xining 810001, China
2 Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China

Received:2020-06-11 Revised:2020-10-24 Online:2021-04-30 Published:2021-04-30
Contact: WANG Zhi-xin
Supported by:
Second Batch of Qinghai Province “High-end Innovative Talents Thousand Talents Program” Project(aiming to cultivate top talents);Chinese Academy of Sciences “Western Light” (young scholars)Project;Qinghai University Affiliated Hospital Key Project of Research Funds for Young and Middle-age Researchers(ASRF-2016-01)

摘要/Abstract

摘要：

多房棘球蚴病是由多房棘球绦虫续绦期幼虫感染人体引起,从而出现严重临床表现并伴有高致死率的疾病,原发于宿主肝脏,引起肝细胞损伤。多房棘球蚴感染对宿主肝细胞胶原基因产生、细胞周期改变、介导宿主免疫应答、信号通路激活和相关基因的表达等均产生影响。本文对该作用机制进行综述,为治疗多房棘球蚴病提供有价值的参考。

关键词: 多房棘球蚴病, 多房棘球绦虫, 肝细胞损害

Abstract:

Alveolar echinococcosis is a disease caused by infection of Echinococcus multilocularis metacestode, which leads to severe clinical symptoms with high mortality. This disease develops from the host liver, damaging hepatocytes. E. multilocularis metacestode infection could affect the expression of hepatocyte collagen gene, cell cycle alteration, mediation of host immune responses, activation of signaling pathways and expression of related genes. This paper reviews the mechanisms damaging the host hepatocytes to provide useful reference information for treatment of alveolar echinococcosis.

Key words: Alveolar echinococcosis, Echinococcus multilocularis, Hepatocyte damage

中图分类号:

R532.32

徐凯, 王海久, 张丽, 张耀刚, 樊海宁, 任利, 任宾, 王志鑫. 多房棘球蚴对宿主肝细胞损害机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(2): 256-259.

XU Kai, WANG Hai-jiu, ZHANG Li, ZHANG Yao-gang, FAN Hai-ning, REN Li, REN Bin, WANG Zhi-xin. Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(2): 256-259.

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多房棘球蚴对宿主肝细胞损害机制的研究进展

Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis

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