细胞程序性死亡在棘球蚴病中的研究进展

doi:10.12140/j.issn.1000-7423.2024.02.018

中国寄生虫学与寄生虫病杂志 ›› 2024, Vol. 42 ›› Issue (2): 259-266.doi: 10.12140/j.issn.1000-7423.2024.02.018

细胞程序性死亡在棘球蚴病中的研究进展

达哇卓玛¹^,²(), 刘川川²^,³, 樊海宁²^,³^,^*()

1 青海大学高原医学研究中心，西宁 810001
2 青海省包虫病研究重点实验室，西宁 810001
3 青海大学附属医院，西宁 810001

收稿日期:2023-12-07 修回日期:2024-01-28 出版日期:2024-04-30 发布日期:2024-04-25
通讯作者: * 樊海宁（1970—），男，博士，主任医师，从事肝胆胰外科临床与基础研究。E-mail：fanhaining@medmail.com.cn
作者简介:达哇卓玛（1993—），女，博士研究生，主治医师，从事地方病临床与基础研究工作。E-mail：dawazhuoma5031@163.com
基金资助:
青海省科技厅基础研究计划(2023-ZJ-992Q)

Research on the progress of programmed cell death in echinococcosis

DAWA Zhuoma¹^,²(), LIU Chuanchuan²^,³, FAN Haining²^,³^,^*()

1 Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
2 Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China
3 Qinghai University Affiliated Hospital, Xining 810000, China

Received:2023-12-07 Revised:2024-01-28 Online:2024-04-30 Published:2024-04-25
Contact: * E-mail: fanhaining@medmail.com.cn
Supported by:
Province Natural Science Foundation of Qinghai(2023-ZJ-992Q)

摘要/Abstract

摘要：

棘球蚴病是由细粒棘球绦虫和多房棘球绦虫的中绦期幼虫感染引起的人兽共患病，人类作为易感中间宿主通过偶然食入了虫卵被幼虫感染。细胞程序性死亡在棘球绦虫生长发育过程中普遍存在，与其生长发育、组织修复和疾病产生有关。细胞程序性死亡包括在发育和组织稳态中的经典凋亡以及在外源性和内源性微环境中发生的其他形式如焦亡、自噬、铁死亡等。本文对多种程序性细胞死亡途径在棘球蚴病发生发展中的作用以及药物干预研究作一综述，以期为棘球蚴病预防和治疗中寻找潜在靶标提供理论资料。

关键词: 多房棘球绦虫, 细粒棘球绦虫, 程序性死亡, 凋亡, 焦亡, 自噬, 铁死亡

Abstract:

Echinococcosis is a serious zoonosis disease caused by the metacestode stage larval of Echinococcus granulosus and E. mulculoris. Humans as an intermediate host infected by the larvae stages of the parasites through accidental ingestion of the eggs. Programmed cell death is common in the growth and development of Echinococcus. Programmed cell death includes apoptosis, pyroptpsis, autophagy and ferroptosis. In this review, we summarized the role of programmed cell death pathways in the echinococcosis and try to provide a basic theoryto explore potential targets for the prevention and treatment of echinococcosis.

Key words: Echinococcus mulculoris, E. granulosus, Programmed cell death, Apoptosis, Pyroptpsis, Autophagy, Ferroptosis

中图分类号:

R532.32

达哇卓玛, 刘川川, 樊海宁. 细胞程序性死亡在棘球蚴病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(2): 259-266.

DAWA Zhuoma, LIU Chuanchuan, FAN Haining. Research on the progress of programmed cell death in echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(2): 259-266.

图/表 4

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图4

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细胞程序性死亡在棘球蚴病中的研究进展

Research on the progress of programmed cell death in echinococcosis

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