蜱类保护性抗原研究进展

doi:10.12140/j.issn.1000-7423.2021.04.020

摘要/Abstract

摘要：

蜱是一种专性吸血的体外寄生虫,可传播多种病原体,给人类健康和畜牧业发展带来极大危害。筛选高效的保护性抗原用于研制抗蜱疫苗已成为安全有效的蜱类防治新策略。本文简要介绍了商业化的Bm86保护性抗原,着重对蜱类唾液腺、中肠、生殖腺和卵内保护性抗原及酶类、蛋白酶抑制剂、保守性蛋白等不同特性的保护性抗原进行归纳总结,为后续研制抗蜱疫苗提供科学依据。

关键词: 蜱, 保护性抗原, 抗蜱疫苗

Abstract:

Ticks are obligate hematophagous ectoparasites that can transmit a variety of pathogens, having harmful impacts on human health and the husbandry industry. Screening for efficient protective antigens to develop anti-tick vaccines has become a safe and effective strategy for tick control. This paper briefly introduces the commercial Bm86 protective antigen, and summarizes current status of protective antigens with different characteristics derived from tick salivary glands, midgut, gonads and eggs, as well as protective antigens of enzymes, protease inhibitors and conservative proteins. The review will provide a scientific basis for the development of anti-tick vaccines.

Key words: Tick, Protective antigen, Anti-tick vaccine

中图分类号:

R384.41

吕立红, 张金成, 胡永红. 蜱类保护性抗原研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(4): 542-547.

LV Li-hong, ZHANG Jin-cheng, HU Yong-hong. Research progress on tick protective antigens[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(4): 542-547.

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