中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (5): 625-630.doi: 10.12140/j.issn.1000-7423.2023.05.015
刘岳青1,2(), 马林源2, 陈开廷2, 高金亮2, 王鹏1,*(
)
收稿日期:
2023-06-02
修回日期:
2023-09-12
出版日期:
2023-10-30
发布日期:
2023-11-06
通讯作者:
*王鹏(1978-),男,硕士,主任技师,从事临床检验技术的开发与应用研究。E-mail:作者简介:
刘岳青(1998-),男,硕士,初级检验师,从事蜱源抗凝蛋白研究。E-mail:15044857509@163.com
基金资助:
LIU Yueqing1,2(), MA Linyuan2, CHEN Kaiting2, GAO Jinliang2, WANG Peng1,*(
)
Received:
2023-06-02
Revised:
2023-09-12
Online:
2023-10-30
Published:
2023-11-06
Contact:
*E-mail: Supported by:
摘要:
蜱是一类体外吸血寄生虫,在吸血过程中蜱会向宿主体内释放多种抗凝血物质以保证血液的供应。其中含Kunitz结构域的丝氨酸蛋白酶抑制剂在抗凝血作用中占主要地位。不同的Kunitz型丝氨酸蛋白酶抑制剂具有相似的保守序列,但总体结构不同,在凝血级联中通过抑制丝氨酸蛋白酶类的凝血因子而阻断下游凝血因子的活化,以达到抑制凝血的效果。蜱源Kunitz型丝氨酸蛋白酶抑制剂在凝血系统中的靶点繁多且抑制机制各异。本文对该类蛋白酶抑制剂的抗凝靶点及作用机制进行归纳,有助于抗凝和抗血栓药物的研发,同时进一步解释蜱与宿主间的相互作用以及蜱源抗凝药物的药理作用,为预防蜱对宿主的侵害提供参考资料。
中图分类号:
刘岳青, 马林源, 陈开廷, 高金亮, 王鹏. 蜱源Kunitz型丝氨酸蛋白酶抑制分子的结构与功能研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 625-630.
LIU Yueqing, MA Linyuan, CHEN Kaiting, GAO Jinliang, WANG Peng. Research progress on the structure and function of tick-derived serine protease inhibitor containing Kunitz domains[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(5): 625-630.
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