关键词: 恶性疟原虫, 酮替芬, 赛庚啶, 苯噻啶, 体外培养, 抑制作用, 裂殖体, 滋养体, 环状体, 寄生虫病研究所

Abstract: We have reported that ketotifen, cyproheptadinee and pizotifenum could cure mice infected with Plasmodium yoelii, and kctotifen and cyproheptadine could cure monkeys infected with Plasmodium cynomolgi. This paper presems the inhibitory effect of the above-mentioncd thrce drugs in vitro on the development of Plasmodium falciparum. 5 × 10-5M ketotifen, 1 × 10-4 M cyproheptadin and pizotifenum inhibited the trophozoites from developing into schizonts, which became degencrated 30 hours after drug exposure.