寄生原虫感染对宿主肠道菌群影响的研究进展

doi:10.12140/j.issn.1000-7423.2026.01.018

中国寄生虫学与寄生虫病杂志 ›› 2026, Vol. 44 ›› Issue (1): 124-129.doi: 10.12140/j.issn.1000-7423.2026.01.018

寄生原虫感染对宿主肠道菌群影响的研究进展

李鹏瑶¹^,²^,³()(), 李静¹^,²^,³, 郑斌¹^,²^,³, 陆绍红¹^,²^,³^,^*()()

¹ 杭州医学院，浙江杭州 310013
² 防控新型疫苗浙江省工程研究中心，浙江杭州 310013
³ 全省高等级生物安全与生物医药转化重点实验室，浙江杭州 310013

收稿日期:2025-07-22 修回日期:2025-11-19 出版日期:2026-02-28 发布日期:2026-02-13
通讯作者: * 陆绍红（ORCID：0000-0001-9855-7154），女，博士，研究员，从事病原微生物研究。E-mail：llsshh2003@163.com
作者简介:李鹏瑶（ORCID：0009-0007-0868-0011），男，硕士研究生，从事病原微生物研究。E-mail：mikelpy@foxmail.com
基金资助:
浙江省科技计划全省重点实验室项目(2025ZY01054);浙江省自然科学基金(LMS25H190001)

Advances in the effects of parasitic protozoan infections on the host gut microbiota

LI Pengyao¹^,²^,³()(), LI Jing¹^,²^,³, ZHENG Bin¹^,²^,³, LU Shaohong¹^,²^,³^,^*()()

¹ Hangzhou Medical College, Hangzhou 310013, Zhejiang, China
² Zhejiang Provincial Engineering Research Centre for Novel Vaccine Prevention and Control, Hangzhou 310013, Zhejiang, China
³ Provincial Key Laboratory of High-Level Biosafety and Biomedical Translation, Hangzhou 310013, Zhejiang, China

Received:2025-07-22 Revised:2025-11-19 Online:2026-02-28 Published:2026-02-13
Contact: *E-mail: llsshh2003@163.com
Supported by:
Zhejiang Provincial Key Laboratory Project under the Provincial Science and Technology Plan(2025ZY01054);Zhejiang Natural Science Foundation(LMS25H190001)

摘要/Abstract

摘要：

肠道菌群作为宿主健康的重要调节因子，其在寄生原虫感染过程中的作用受到广泛关注。多种寄生原虫可通过直接侵袭肠道上皮、激活炎症反应、破坏肠屏障或改变代谢通路诱导宿主肠道菌群失调，具体表现为有益菌减少、致病菌增殖及菌群多样性下降。刚地弓形虫和蓝氏贾第鞭毛虫可引发菌群重构并持续影响宿主代谢，利什曼原虫和锥虫在其传播媒介肠道内的发育过程受微生物群显著影响，媒介共生菌可对病原体的生长与分化发挥促进或抑制作用。肠道菌群不仅影响寄生虫定植和感染程度，还可通过其代谢产物（如短链脂肪酸、吲哚类、胆汁酸）调节宿主免疫应答，成为寄生虫感染过程中不可忽视的关键调节因子。本文对重要寄生原虫感染引起的肠道菌群改变及其潜在的作用机制进行综述，旨在为深入理解其致病过程及微生态干预策略的开发提供参考。

关键词: 寄生原虫, 肠道菌群, 作用机制

Abstract:

Gut microbiota, as a crucial regulator of host health, has received growing attention for its role in parasitic protozoan infections. A variety of parasitic protozoa may induce host gut microbiota dysbiosis through direct invasion of intestinal epithelium, activation of inflammatory responses, disruption of intestinal barriers, or alterations in metabolic pathways, and this dysbiosis is characterized by a decrease in beneficial bacteria, proliferation of pathogenic bacteria, and a reduction in microbial diversity. Toxoplasma gondii and Giardia lamblia have been found to induce microbiota remodeling and persistently affect host metabolism, while the development of Leishmania and Trypanosoma in the intestines of their transmitting vectors are remarkably affected by microbiota. In addition, symbiotic bacteria may promote or inhibit pathogen growth and differentiation. Gut microbiota not only affects parasite colonization and infection severity but also modulates host immune responses through metabolites such as short-chain fatty acids, indoles, and bile acids, which is a non-negligible key regulator during parasitic infections. This review summarizes the alterations in gut microbiota caused by major parasitic protozoan infections and their potential mechanisms of actions, so as to provide insights into better understanding of pathogenesis and development of microecological intervention strategies.

Key words: Parasitic protozoa, Gut microbiota, Mechanism of action

中图分类号:

R382

李鹏瑶, 李静, 郑斌, 陆绍红. 寄生原虫感染对宿主肠道菌群影响的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2026, 44(1): 124-129.

LI Pengyao, LI Jing, ZHENG Bin, LU Shaohong. Advances in the effects of parasitic protozoan infections on the host gut microbiota[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2026, 44(1): 124-129.

参考文献 41

[1]	Ni J, Wu GD, Albenberg L, et al. Gut microbiota and IBD: Causation or correlation?[J]. Nat Rev Gastroenterol Hepatol, 2017, 14(10): 573-584.
[2]	Sun YG, Zhang SS, Nie QX, et al. Gut firmicutes: Relationship with dietary fiber and role in host homeostasis[J]. Crit Rev Food Sci Nutr, 2023, 63(33): 12073-12088.
[3]	Lapébie P, Lombard V, Drula E, et al. Bacteroidetes use thousands of enzyme combinations to break down glycans[J]. Nat Commun, 2019, 10(1): 2043.
[4]	Alwali AY, Parkinson EI. Small molecule inducers of Actinobacteria natural product biosynthesis[J]. J Ind Microbiol Biotechnol, 2023, 50(1): kuad019.
[5]	Blount ZD. The unexhausted potential of E. coli[J]. eLife, 2015, 4: e05826.
[6]	MacFarlane S, MacFarlane GT. Regulation of short-chain fatty acid production[J]. Proc Nutr Soc, 2003, 62(1): 67-72.
[7]	Ichinohe T, Pang IK, Kumamoto Y, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection[J]. Proc Natl Acad Sci USA, 2011, 108(13): 5354-5359.
[8]	Liesenfeld O. Oral infection of C57BL/6 mice with Toxoplasma gondii: A new model of inflammatory bowel disease?[J]. J Infect Dis, 2002, 185(Suppl 1): S96-S101.
[9]	Lipoldová M. Giardia and vilém du?an lambl[J]. PLoS Negl Trop Dis, 2014, 8(5): e2686.
[10]	彭晓雪, 王旭, 简金花, 等. 我国人群蓝氏贾第鞭毛虫感染及食源性污染现状[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(2): 274-280, 285.
	Peng XX, Wang X, Jian JH, et al. Giardia lamblia infection in the population and foodborne contamination in China[J]. Chin J Parasitol Parasit Dis, 2025, 43(2): 274-280, 285. (in Chinese)
[11]	Riba A, Hassani K, Walker A, et al. Disturbed gut microbiota and bile homeostasis inGiardia-infected mice contributes to metabolic dysregulation and growth impairment[J]. Sci Transl Med, 2020, 12(565): eaay7019.
[12]	Giallourou N, Arnold J, McQuade ETR, et al. Giardia hinders growth by disrupting nutrient metabolism independent of inflammatory enteropathy[J]. Nat Commun, 2023, 14(1): 2840.
[13]	Bhatt AP, Arnold JW, Awoniyi M, et al. Giardia antagonizes beneficial functions of indigenous and therapeutic intestinal bacteria during protein deficiency[J]. Gut Microbes, 2024, 16(1): 2421623.
[14]	Walana W, Adam MG, Tamomh AG. Prevalence and genetic diversity of Giardia duodenalis in Africa: A review[J]. J Parasitol Res, 2025, 2025: 1232330.
[15]	聂恩琼, 夏尧, 汪涛, 等. One Health: 应对新发传染病的新理念[J]. 微生物与感染, 2016, 11(1): 3-7.
	Nie EQ, Xia Y, Wang T, et al. One Health: A new approach to control emerging infectious diseases[J]. J Microbes Infect, 2016, 11(1): 3-7. (in Chinese)
[16]	Fekete E, Allain T, Sosnowski O, et al. Giardia spp. -induced microbiota dysbiosis disrupts intestinal mucin glycosylation[J]. Gut Microbes, 2024, 16(1): 2412676.
[17]	Kotloff KL, Nataro JP, Blackwelder WC, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): A prospective, case-control study[J]. Lancet, 2013, 382(9888): 209-222.
[18]	Nader JL, Mathers TC, Ward BJ, et al. Evolutionary genomics of anthroponosis in Cryptosporidium[J]. Nat Microbiol, 2019, 4(5): 826-836.
[19]	Greigert V, Saraav I, Son J, et al. Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus[J]. Gut Microbes, 2024, 16(1): 2297897.
[20]	de Sablet T, Potiron L, Marquis M, et al. Cryptosporidium parvum increases intestinal permeability through interaction with epithelial cells and IL-1β and TNFα released by inflammatory monocytes[J]. Cell Microbiol, 2016, 18(12): 1871-1880.
[21]	VanDussen KL, Funkhouser-Jones LJ, Akey ME, et al. Neonatal mouse gut metabolites influence Cryptosporidium parvum infection in intestinal epithelial cells[J]. mBio, 2020, 11(6): e02582-e02520.
[22]	Montoya J, Liesenfeld O. Toxoplasmosis[J]. Lancet, 2004, 363(9425): 1965-1976.
[23]	Molloy MJ, Grainger JR, Bouladoux N, et al. Intraluminal containment of commensal outgrowth in the gut during infection-induced dysbiosis[J]. Cell Host Microbe, 2013, 14(3): 318-328.
[24]	Meng JX, Wei XY, Guo HP, et al. Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii[J]. Front Immunol, 2023, 14: 1156397.
[25]	Chen JT, Zhang C, Yang ZH, et al. Intestinal microbiota imbalance resulted by anti-Toxoplasma gondii immune responses aggravate gut and brain injury[J]. Parasit Vectors, 2024, 17(1): 284.
[26]	Sanchez SG, Besteiro S. The pathogenicity and virulence of Toxoplasma gondii[J]. Virulence, 2021, 12(1): 3095-3114.
[27]	Mo RX, Zhang MR, Wang HT, et al. Chitosan enhances intestinal health in cats by altering the composition of gut microbiota and metabolites[J]. Metabolites, 2023, 13(4): 529.
[28]	Dubey JP, Lindsay DS, Speer CA. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts[J]. Clin Microbiol Rev, 1998, 11(2): 267-299.
[29]	Yang J, Liu SH, Zhao Q, et al. Gut microbiota-related metabolite alpha-linolenic acid mitigates intestinal inflammation induced by oral infection with Toxoplasma gondii[J]. Microbiome, 2023, 11(1): 273.
[30]	Sriboonvorakul N, Chotivanich K, Silachamroon U, et al. Intestinal injury and the gut microbiota in patients with Plasmodium falciparum malaria[J]. PLoS Pathog, 2023, 19(10): e1011661.
[31]	Phu NH, Day NPJ, Tuan PQ, et al. Concomitant bacteremia in adults with severe falciparum malaria[J]. Clin Infect Dis, 71(9): e465-e470.
[32]	Van Den Ham KM, Bower LK, Li SP, et al. The gut microbiome is associated with susceptibility to febrile malaria in Malian children[J]. Nat Commun, 2024, 15(1): 9525.
[33]	Feng YB, Peng YQ, Song XM, et al. Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota[J]. Nat Microbiol, 2022, 7(5): 707-715.
[34]	高春花, 管立人, 汪俊云. 利什曼原虫的传播机制及传媒蛉种的研究进展[J]. 国际医学寄生虫病杂志, 2007, 34(3): 113-118.
	Gao CH, Guan LR, Wang JY. Research progress on transmission mechanism of human Leishmania and their vector sandfly species[J]. Int J Med Parasit Dis, 2007, 34(3): 113-118. (in Chinese)
[35]	Serafim TD, Coutinho-Abreu IV, Dey R, et al. Leishmaniasis: The act of transmission[J]. Trends Parasitol, 2021, 37(11): 976-987.
[36]	Dey R, Joshi AB, Oliveira F, et al. Gut microbes egested during bites of infected sand flies augment severity of leishmaniasis via inflammasome-derived IL-1β[J]. Cell Host Microbe, 2018, 23(1): 134-143.e6.
[37]	Mrázek J, Mrázková L, Mekadim C, et al. Effects of Leishmania major infection on the gut microbiome of resistant and susceptible mice[J]. Appl Microbiol Biotechnol, 2024, 108(1): 145.
[38]	王盛书, 尹红, 王善雨, 等. 美洲锥虫病研究进展[J]. 解放军预防医学杂志, 2013, 31(6): 556-558.
	Wang SS, Yin H, Wang SY, et al. Research progress on American trypanosomiasis[J]. J Prev Med Chin PLA, 2013, 31(6): 556-558. (in Chinese)
[39]	Cambronero-Heinrichs JC, Rojas-G?tjens D, Baizán M, et al. Highly abundant bacteria in the gut of Triatoma dimidiata (Hemiptera: Reduviidae) can inhibit the growth of Trypanosoma cruzi (Kinetoplastea: Trypanosomatidae)[J]. J Med Entomol, 2024, 61(6): 1333-1344.
[40]	Omondi ZN, Caner A, Arserim SK. Trypanosomes and gut microbiota interactions in triatomine bugs and tsetse flies: A vectorial perspective[J]. Med Vet Entomol, 2024, 38(3): 253-268.
[41]	Dumonteil E, Tu WH, Jiménez FA, et al. Ecological interactions of Triatoma sanguisuga (Hemiptera: Reduviidae) and risk for human infection with Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae) in Illinois and Louisiana[J]. J Med Entomol, 2024, 61(6): 1282-1289.

寄生原虫感染对宿主肠道菌群影响的研究进展

Advances in the effects of parasitic protozoan infections on the host gut microbiota

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