CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2021, Vol. 39 ›› Issue (6): 832-835.doi: 10.12140/j.issn.1000-7423.2021.06.016

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Advances in research of structure, function and regulatory mechanism of Toxoplasma gondii conoid

ZHANG Xiao-han(), FENG Ying, CHEN Ran, SANG Xiao-yu, YANG Na*()   

  1. College of Animal Husbandry and Veterinary Medicine, Shengyang Agricultural University, Shengyang 110866, China
  • Received:2021-04-28 Revised:2021-07-31 Online:2021-12-30 Published:2021-12-05
  • Contact: YANG Na;
  • Supported by:
    General Project of National Natural Science Foundation of China(31672546);General Project of National Natural Science Foundation of China(32072891)


The apical complex is the typical structure of phylum Apicomplexa which consists secretory organelles and cytoskeletal elements, of which a marked feature is the conoid formed by tubulin fibers. Toxoplasma gondii has a relatively intact conoid, thus, it provides a successful model for analyzing the structure, composition and function of conoid. The stability and relevant activities of conoid are closely related to gliding motility and microneme secretion in of Toxoplasma, and are critical for host cell invasion. In this paper, the structure stability, protein function and regulatory mechanism of conoid are reviewed.

Key words: Toxoplasma gondii, Conoid, Gliding motility, Invasion, Calcium regulation

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