CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2021, Vol. 39 ›› Issue (6): 826-831.doi: 10.12140/j.issn.1000-7423.2021.06.015

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Research progress on the interaction between host cell autophagy and apicomplexa protozoa infection

LU Fei(), ZHUO Xun-hui, LU Shao-hong*()   

  1. School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou 310000, China
  • Received:2021-05-24 Revised:2021-08-09 Online:2021-12-30 Published:2021-12-13
  • Contact: LU Shao-hong;
  • Supported by:
    Natural Science Foundation of China(81802037);National Natural Science Foundation of China(81871684);Key Research and Development Project of Zhejiang Province(2019C03057);Qingshan Lake United Fund of Zhejiang Province(LQY19H190002)


Autophagy is a conserved lysosome-depenendant degradation system widely present in eukaryotes, and intracellular substances are transported to lysosomes for degradation through this mechanism, which plays an important role in cell survival under stress conditions of starvation and hypoxia. In addition, cells can also eliminate foreign pathogens such as parasites and viruses through the clearance action of autophagy. Apicomplexa protozoa are obligatory intracellular parasites, often zoonotic pathogens, posing considerable threats to social development and public health. In recent years, researches on the interaction between autophagy and apicomplexa protozoa mainly focused on Toxoplasma gondii and Plasmodium. In this paper, we reviewed the progress of research on the interaction between autophagy and important Apicomplexa protozoa infection.

Key words: Autophagy, Apicomplexan, Toxoplasma gondii, Plasmodium

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