The role of type Ⅰ interferon in protozoan infections

Abstract

Abstract:

Plasmodium spp., Toxoplasma gondii, Leishmania spp., and Trypanosoma spp. are protozoa that pose a serious health threat to humans. There has been accumulating evidence for an important role of type Ⅱ interferon (IFN-Ⅱ) against parasite infection. However, little is known on the role of IFN-Ⅰ in host defense against parasites. The IFN-Ⅰ responses induced by protozoal infection may vary according to the parasite species/strain, parasite burder, parasite develpmental stage, and the host genetic background. In addition, there are interactions between IFN-Ⅰ and IFN-Ⅱ during protozoan infection. This review summarizes recent findings on the role of IFN-Ⅰ and its regulatory mechanisms during protozoan infection.

Key words: TypeⅠinterferon, Plasmodium spp., Toxoplasma gondii, Leishmania spp., Trypanosoma spp.

CLC Number:

R531

Yuan-lin MA, Fang-li LYU. The role of type Ⅰ interferon in protozoan infections[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(4): 399-404.

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