Approaches to screening and identifying genes associated with drug-resistance of Plasmodium falciparum

Abstract

Abstract:

Plasmodium falciparum has developed resistance to almost all currently available antimalaria drugs. The emergence of resistance to artemisinin and the alike in recent years has greatly challenged the global malaria control and elimination. Thus, screening and identifying genes associated with the drug resistance is of great significance to elucidate the action mechanism of antimalarials, monitor the occurrence and spread of resistance, and set up guidelines for antimalarial drug use. This paper summarizes the approaches to screen and identify the genes associated with drug resistance of P. falciparum.

Key words: Plasmodium falciparum, Drug resistance gene, Candidate gene approach, Linkage analysis, Genome-wide association analysis

CLC Number:

R382.312

Yi-ni TIAN, Run YE, Wei-qing PAN, Dong-mei ZHANG. Approaches to screening and identifying genes associated with drug-resistance of Plasmodium falciparum[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2017, 35(5): 495-498.

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