Research progress on microRNAs of ticks

doi:10.12140/j.issn.1000-7423.2020.06.016

Abstract

Abstract:

MicroRNAs (miRNAs) are a class of non-coding small RNA molecules involved in the regulation of development, stress, cell differentiation, cell apoptosis and other physiological and cellular processes. Ticks, as obligate blood-sucking ectoparasites, serve as a vector of a great diversity of pathogens. Research on the miRNAs of ticks has mainly focused on their regulation of growth and development, as well as their roles in functional regulation during the tick-pathogen interactions. This paper reviews the recent progress on the identification of miRNAs in ticks and their roles in functional regulation, which may provide a theoretical basis for subsequent design of prevention and control strategies for ticks and tick-borne diseases.

Key words: Tick, microRNA, Biological function, Regulatory mechanism, Pathogen transmission

CLC Number:

R384.41

PEI Ting-wei, YU Zhi-jun, LIU Jing-ze. Research progress on microRNAs of ticks[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(6): 771-776.

Figures/Tables 1

References 51

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物种	miRNA	靶基因	生物学功能
长角血蜱 Haemaphysalis longicornis	miR-278^[33]	未知	注射拮抗剂后饱血率下降,死亡率上升
	miR-275^[43]	Vg-2	注射拮抗剂后卵巢发育受损,产卵量下降
	miR-184^[44]	Vg	注射拮抗剂后饱血体重下降,产卵量下降,产卵周期变长
	miR-375^[45]	未知	注射拮抗剂后产卵量下降,部分卵干燥、孵化率下降
亚洲璃眼蜱Hyalomma asiaticum	miR-10^[41]	未知	在吸血初期表达量上调,随吸血时间延长表达量逐渐下调,调控蜱类吸血过程
	miR-451^[42]	MIF	miR-451上调负调控MIF表达
	Let-7^[46]	ECR	注射Let-7类似物使其过表达时,蜱类蜕皮时间延长
镰形扇头蜱 Rhipicephalus haemaphysaloides	miR-303^[37]	未知	可靶向调控免疫通路相关基因
	miR-9^[37]	未知	在LPS激活的抗炎调节中发挥重要作用
肩突硬蜱Ixodes scapularis	miR-79^[7]	Robo2	嗜吞噬细胞无形体通过靶向Robo2途径上调miR-79,减少保护性促炎症反应