CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2020, Vol. 38 ›› Issue (2): 146-151.doi: 10.12140/j.issn.1000-7423.2020.02.003
• ORIGNAL ARTICLES • Previous Articles Next Articles
Shu-ping LIU1, Ying DONG2,*(), Yan-chun XU2, Yan LIU2, Yan DENG2, Cang-lin ZHANG2, Meng-ni CHEN2
Received:
2019-11-21
Online:
2020-04-30
Published:
2020-05-11
Contact:
Ying DONG
E-mail:luxidongying@126.com
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CLC Number:
Shu-ping LIU, Ying DONG, Yan-chun XU, Yan LIU, Yan DENG, Cang-lin ZHANG, Meng-ni CHEN. The mutation polymorphism of G6PD gene coding region in vivax malaria patients in Yunnan Province, China[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(2): 146-151.
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URL: https://www.jsczz.cn/EN/10.12140/j.issn.1000-7423.2020.02.003
Table 1
Predicted mutation sites and alleles based on the cDNA sequences of G6PD gene from malaria vivax patients
位点Loci | 单位点突变Singleton variable sites | 位点等位Alleles of locus | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
碱基 替换 Base substitution | 密码改变Codon change | 变异Variation | 频率/10-5 Frequency/10-5 | 半合子Hemizygote | 合子 Zygote | |||||||||||
非突变(NM)Nonmutation (NM) | 突变(M) Mutation (M) | 非突变纯合 (NM/NM) NMHb (NM/NM) | 突变杂合(NM/M)NMHc (NM/M) | 突变纯合(M/M)MHe (M/M) | ||||||||||||
数量(构成比/%) No. (CR/%)a | G6PDdd | 数量(构成比/%) No. (CR/%)a | G6PDdd | 数量(构成比/%)No. (CR/%)a | G6PDdd | 数量(构成比/%)No. (CR/%)a | G6PDdd | 数量(构成比/%)No. (CR/%)a | G6PDdd | |||||||
c.461 | T > A | ATT > AAT | I154N | 1.5 | 24 (54.5) | 0 | 1 (2.3) | 0 | 19 (43.2) | 0 | - | - | - | - | ||
c.574 | C > T | CGT > TGT | R192C | 1.5 | 24 (54.5) | 0 | 1 (2.3) | 0 | 19 (43.2) | 0 | - | - | - | - | ||
c.786 | C > T | AAC > ATG | N262N | 1.5 | 24 (54.5) | 0 | 1 (2.3) | 0 | 19 (43.2) | 0 | - | - | - | - | ||
c.1059 | C > T | CAC > AAT | P353P | 1.5 | 25 (56.8) | 0 | - | 18 (40.9) | 0 | - | - | 1 (2.3) | 0 | |||
c.1311 | T > C | TAT > TAC | Y437Y | 45.6 | 9 (20.4) | 0 | 16 (36.4) | 1 | 5 (11.4) | 0 | 10 (22.7) | 0 | 4 (9.1) | 0 | ||
c.1376 | G > T | CGT > CTT | R459L | 1.5 | 24 (54.5) | 0 | 1 (2.3) | 1 | 19 (43.2) | 0 | - | - | - | - |
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