Evaluation of the effectiveness of the integrated clonorchiasis control programme in Guangdong Province

doi:10.12140/j.issn.1000-7423.2025.06.008

Abstract

Abstract:

Objective To investigate the effectiveness of the integrated clonorchiasis control programme in hyperendemic areas of Guangdong Province (Zhongshan City and Xinhui District of Jiangmen City), so as to provide reproducible and scalable integrated control experiences in other disease-affected regions. Methdos Integrated clonorchiasis control measures were implemented in Zhongshan City and Xinhui District of Jiangmen City during the period from 2019 to 2023, including online and offline health education, environmental improvements focusing on construction of sanitary toilets and provision of safe water in the text of new rural construction, albendazole given to Clonorchis sinensis-infected individuals, improvements of professional capabilities among disease control teams by means of training and hands-on practices. An administrative village (community) was selected from each township (street) in eastern, western, southern, northern and central parts according to geographical locations in two implementation areas after implementation of the integrated control measures. A total of 200 residents at ages of over 3 years were sampled using the cluster sampling method for detection of the prevalence of human clonorchiasis. And use the findings from the most recent population infection survey conducted prior to the project’s initiation as baseline data for comparison. In addition, a total of 150 individuals were randomly sampled from residents subjected to surveys of the prevalence of C. sinensis human infections in 2019 prior to the programme and 2023 at the final evaluation for questionnaire surveys of healthy human behaviors. Results There were 227 administrative villages received health education pertaining to clonorchiasis control knowledge in Zhongshan City, and 224 in Xinhui District, with a coverage rate of 100% in both areas from 2019 to 2023. The awareness of human clonorchiasis control knowledge was 96.0% (261/272) in Zhongshan City and 98.0% (245/250) in Xinhui District in 2023, which increased by 60.0% and 40.0% relative to 2019 before implementation of the programme [60.0% (150/250) and 70.0% (105/150)], respectively. In terms of environmental improvements, 89 850 new sanitary toilets were built and 89 850 households with access to safe water were provided in Zhongshan City, and 17 094 new sanitary toilets were built and 16 968 households with access to safe water were provided in Xinhui District, with 100% coverage rates of sanitary toilets and safe water supply in both areas. There were 10 424 and 22 427 C. sinensis-infected individuals identified through community-based surveys on human infections and standardized clonorchiasis clinics in medical institutions in Zhongshan City and Xinhui District, and 10 185 and 16 821 individuals given deworming chemicals, with deworming coverage rates of 97.71% and 75.00%, respectively. The proportion of professionals receiving training increased from 91.67% (66/72) to 100% (103/103) in Zhongshan City and from 52.94% (90/170) to 98.05% (201/205) in Xinhui District. The prevalence of C. sinensis infections reduced from 37.28% (400/1 073) at baseline to 11.52% (131/1 137) at the final evaluation in Zhongshan City (χ² = 625.24, P < 0.05) and from 34.18% (499/1 460) to 10.20% (102/1 000) in Xinhui District following implementation of 5-year integrated control programmes (χ² = 188.35, P < 0.05), respectively. Conclusion Through systematic interventions, Zhongshan City and Xinhui District in Guangdong Province significantly reduced the infection rate of C. sinensis, enhanced public awareness of prevention knowledge, and improved environmental sanitation, providing replicable and scalable experiences for comprehensive control in other regions.

Key words: Clonorchiasis, Integrated control, Guangdong Province

CLC Number:

R532.23

ZHANG Guanting, ZHANG Xianchang, ZHANG Qiming, LUO Le, ZENG Qingsheng, FANG Yueyi, LIAO Yuhuang, MAO Qiang, LIU Jiahui, DENG Zhuohui, WU De, CHEN Jingdiao. Evaluation of the effectiveness of the integrated clonorchiasis control programme in Guangdong Province[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(6): 800-805.

Figures/Tables 1

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特征 Feature	中山市 Zhongshan City						新会区 Xinhui District
	基线调查^a Baseline investigation^a			终期评估调查 Final evaluation investigation			基线调查^a Baseline investigation^a			终期评估调查 Final evaluation investigation
	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%	检查人数 No. exam’d	感染人数 No. infected	感染率/% Infection rate/%
性别 Gender
男性 Male	547	228	41.68	504	86	17.06	770	344	44.68	478	62	12.97
女性 Female	526	172	32.70	633	45	7.11	690	155	22.46	522	40	7.66
年龄组/岁 Age Group/years
≤ 10	120	14	11.67	265	1	0.38	104	13	12.50	75	4	5.33
11~20	98	25	25.51	31	0	0	155	20	12.90	98	6	6.12
21~30	169	51	30.18	100	4	4.00	116	34	29.31	51	4	7.84
31~40	198	64	32.32	300	36	12.00	275	80	29.09	158	22	13.92
41~50	168	81	48.21	224	43	19.20	333	124	37.24	148	23	15.54
51~60	167	80	47.90	149	32	21.48	278	127	45.68	144	15	10.42
61~70	116	70	60.34	44	11	25.00	140	64	45.71	182	18	9.89
> 70	37	15	40.54	24	4	16.67	59	37	62.71	144	10	6.94
P（χ²）			< 0.05(88.42)^b			< 0.05(77.83)^c			< 0.05(104.67)^d			> 0.05(12.64)