Current status and research progress of triclabendazole resistance in fascioliasis treatment

doi:10.12140/j.issn.1000-7423.2025.05.018

Abstract

Abstract:

Fascioliasis, which caused by Fasciola hepatica and F. gigantica, is a zoonotic parasitic disease that not only affects human health but also poses a serious threat to other mammals, especially herbivores. Triclabendazole (TCBZ) is the first choice for fascioliasis treatment. However, economic data monitoring in health care indicates that the threat of TCBZ resistance has brought challenges to the health of animals in endemic areas and caused huge economic losses. At the same time, clinical reports have also documented treatment failures possibly related to TCBZ resistance, posing risks to the prevention and control of fascioliasis. This article focuses on the current situation of TCBZ treatment failure and/or resistance in fascioliasis, risk factors for TCBZ resistance, resistance mechanisms, progress in new drug development and exploration of new treatment methods, with the aim of providing references for further research on the prevention and control of fascioliasis.

Key words: Fascioliasis, Triclabendazole, Drug resistance, Research progress

CLC Number:

R532.29

CHEN Chong, ZHU Aihong, HUANG Qin. Current status and research progress of triclabendazole resistance in fascioliasis treatment[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(5): 718-722.

References 47

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