Tick-derived anticoagulant proteins and their potential value in the medical field

doi:10.12140/j.issn.1000-7423.2024.06.012

Abstract

Abstract:

Ticks are hematophagous insects that infest both humans and animals. During a blood meal, they inevitably activate the host’s coagulation system. To evade the host’s defense mechanisms, ticks secrete various anticoagulant proteins that regulate the host’s coagulation system, ensuring continuous blood flow. Most anticoagulation proteins are protease inhibitors capable of interacting with coagulation factors or molecules associated with platelet activity to effectively regulate the host’s blood coagulation process. So far, numerous tick-derived anticoagulant molecules with diverse structures have been identified. These molecules exhibit high specificity and strong affinity for their target molecules in the host. Anticoagulants developed from these tick-derived molecules are expected to offer effective anticoagulant activity with a lower risk of bleeding. This article reviews the research progress of some tick-derived anticoagulant molecules, delving into their mechanisms of action and potential clinical application, aiming to inform the development of new anticoagulant drugs.

Key words: Tick, Anticoagulant, Coagulation factor inhibitor, Platelet activity inhibitor

CLC Number:

R384.41

HE Xiaofei, GAO Jinliang. Tick-derived anticoagulant proteins and their potential value in the medical field[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(6): 767-775.

Figures/Tables 1

References 105

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