Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection

doi:10.12140/j.issn.1000-7423.2023.02.015

Abstract

Abstract:

Neutrophil extracellular traps (NETs) are neutrophil-derived extracellular net-like structures that are composed of chromatin and granule proteins. Initial reports demonstrated that the infection of parasites like protozoa and helminths could induce NETs formation, which plays important roles in the immune defence against parasites and immunopathology caused by infection. This review described the mechanisms of NETs formation and the role of NETs in protozoan and helminth infection, which provides new ideas for the prevention and treatment of parasitic diseases.

Key words: Neutrophil, Neutrophil extracellular trap, Protozoan infection, Helminth infection

CLC Number:

R382，R383

LI Chang, DU Xinyue, YAN Min, WANG Zhaojun. Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(2): 219-222.

Figures/Tables 1

References 41

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原虫种类	ROS依赖		染色质解聚信号			NET类型	NET的免疫防御效应	原虫的逃避免疫机制
原虫种类	NOX来源	线粒体来源	NE	MPO	PAD4	NET类型	NET的免疫防御效应	原虫的逃避免疫机制
伊氏锥虫	+	-	+	+	ND	非裂解性NET	捕获限制原虫运动	TatD样脱氧核糖核酸酶
布氏锥虫	-	-	-	+	ND	非裂解性NET	捕获限制原虫运动	TatD样脱氧核糖核酸酶
克氏锥虫	+	ND	ND	ND	+	裂解性NET	捕获限制原虫运动	无
亚马逊利什曼原虫	-	ND	+	ND	-	非裂解性NET	降低原虫活性	3'-核苷酸酶/核酸酶
亚马逊利什曼原虫	+	-	+	-	+	裂解性NET	降低原虫活性	3'-核苷酸酶/核酸酶
杜氏利什曼原虫	-	ND	ND	ND	ND	ND	降低原虫活性	脂肽聚糖
溶组织内阿米巴	-	ND	+	ND	-	ND	无	胆固醇保护作用
恶性疟原虫	ND	ND	+	ND	-	ND	ND	无