Effects of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis

doi:10.12140/j.issn.1000-7423.2019.02.018

Abstract

Abstract:

Schistosomiasis is a zoonotic parasitic disease worldwide caused by the infections of Schistosoma haematobium, S. mansoni and S. japonicum. The schistosomiasis endemic in China is only caused by S. japonicum infection that results in the deposition of eggs in the liver and causes the egg granuloma and eventually the liver fibrosis. The soluble egg antigens secreted by the miracidium induce host strong immune responses that contribute to the egg granuloma and liver fibrosis. Hepatic stellate cells are the central part of liver fibrosis. The regulation of soluble egg antigens on hepatic stellate cells plays important roles in the development of the fibrosis. This article reviews the research progress in the roles of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis.

Key words: Schistosomiasis, Hepatic fibrosis, Soluble egg antigen, Hepatic stellate cell

CLC Number:

R532.21

Xin LIU, Yong-fen QI, Yan-rong YU. Effects of soluble egg antigens on hepatic stellate cells in the progression of schistosomiasis-associated liver fibrosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019, 37(2): 218-222.

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