Research advances on TGF-β/Smad and MAPK signal pathways in Echinococcus

Abstract

Abstract:

Due to the close contact between Echinococcus and the host, both cells of Echinococcus and the host cells secrete various cytokines during infection, which transmit the stimulation signal into the host cells through the cell surface receptors. This process interferes with the immune system of the host and produces immune tolerance, enabling long-term parasitism of Echinococcus within the host. This review summarizes recent findings on the immunoregulatory role of TGF-β/Smad and MAPK signal pathways during Echinococcus infection.

Key words: TGF-β/Smad;, MAPK, Signaling pathway, Echinococcus

CLC Number:

R383.33

Ling-ling WANG, Hai-mei MA, Jian-bing DING. Research advances on TGF-β/Smad and MAPK signal pathways in Echinococcus[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(5): 516-519.

References 43

[1]	Jenkins DJ.WHO/OIE manual on echinococcosis, in humans and animals: a public health problem of global concern[J]. Int J Parasitol, 2001, 31(14): 1717-1718.
[2]	Vuitton DA, Gottstein B.Echinococcus multilocularis and its intermediate host: a model of parasite-host interplay[J]. J Biomed Biotechnol, 2010, 2010: 1-14.
[3]	Bataller R, Brenner DA.Liver fibrosis[J]. J Clin Invest, 2005, 115(2): 209-218.
[4]	Ray K.Liver: hepatic stellate cells hold the key to liver fibrosis[J]. Nat Rev Gastroenterol Hepatol, 2014, 11(2): 74.
[5]	Siracusano A, Delunardo F, Teggi A, et al. Host-parasite relationship in cystic echinococcosis: an evolving story[J]. Clin Dev Immunol, 2012, 2012: 639362.
[6]	赵慧, 白雪, 聂晓涵, 等. 泡球蚴感染小鼠肝脏中IL-10和TGF-β的动态变化[J]. 中国寄生虫学与寄生虫病杂志, 2012, 30(1): 32-35.
[7]	方海瑞, 蒋红群, 徐芳洁, 等. 原头蚴对体外培养小鼠脾细胞中Th细胞亚群的影响[J]. 中国免疫学杂志, 2016, 32(2): 174-177, 183.
[8]	Brehm K.The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction[J]. Med Microbiol Immunol, 2010, 199(3): 247-259.
[9]	倪兴维, 闫鸿斌, 娄忠子, 等. 多房棘球绦虫信号转导体系[J]. 中国寄生虫学与寄生虫病杂志, 2012, 30(3): 233-237.
[10]	李瑶, 林仁勇, 徐琦, 等. 泡球蚴感染对BALB/c小鼠肝脏TGF-β1及其信号蛋白表达的影响[J]. 免疫学杂志, 2011, 27(3): 215-219.
[11]	Huang G, Ye S, Zhou X, et al. Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network[J]. Cell Mol Life Sci, 2015, 72(9): 1741-1757.
[12]	Ravenhall C, Guida E, Harris T, et al. The importance of ERK activity in the regulation of cyclin D1 levels and DNA synthesis in human cultured airway smooth muscle[J]. Br J Pharmacol, 2000, 131(1): 17-28.
[13]	Shi Y, Massagué J.Mechanisms of TGF-beta signaling from cell membrane to the nucleus[J]. Cell, 2003, 113(6): 685-700.
[14]	Fuchs O. Inhibition of TGF-β signaling for the treatment of tumor metastasis and fibrotic diseases[J]. Curr Signal Transduct Ther, 2011, 6(1): 29-43.
[15]	Yoshimura A, Muto G.TGF-β function in immune suppression[J]. Curr Top Microbiol Immunol, 2011, 350: 127-147.
[16]	Hill CS.Nucleocytoplasmic shuttling of Smad proteins[J]. Cell Res, 2009, 19(1): 36-46.
[17]	Stenvers KL, Tursky ML, Harder KW, et al. Heart and liver defects and reduced transforming growth factor beta 2 sensitivity in transforming growth factor beta type Ⅲ receptor-deficient embryos[J]. Mol Cell Biol, 2003, 23(12): 4371-4385.
[18]	张炳远, 张建余, 赵凯, 等. 胆管癌组织Smad4和转化生长因子β1级Ⅱ型受体的表达及意义[J]. 中华外科杂志, 2005, 43(13): 846-849.
[19]	Saika S, Yamanaka O, Nishikawa-Ishida I, et al. Effect of Smad7 gene over expression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model[J]. Arch Ophthalmol, 2007, 125(5): 647-654.
[20]	Lucarelli P, Schilling M, Kreutz C, et al. Resolving the combinatorial complexity of Smad protein complex formation and its link to gene expression[J]. Cell Syst, 2018, 6(1): 75-89.
[21]	Kleiter I, Song J, Lukas D, et al. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis[J]. Brain, 2010, 133(Pt 4): 1067-1081.
[22]	Xu F, Liu C, Zhou D, et al. TGF-β/SMAD pathway and its regulation in hepatic fibrosis[J]. J Histochem Cytochem, 2016, 64(3): 157-167.
[23]	Wang J, Zhang C, Wei X, et al. TGF-β and TGF-β/Smad signaling in the interactions between Echinococcus multilocularis and its hosts[J]. PLoS One, 2013, 8(2): e55379.
[24]	Zhu D, He X, Duan Y, et al. Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum[J]. Parasit Vectors, 2014, 7: 148.
[25]	Barros AF, Oliveira SA, Carvalho CL, et al. Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni[J]. Mem Inst Oswaldo Cruz, 2014, 109(2): 210-219.
[26]	Attia YM, Elalkamy EF, Hammam OA, et al. Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection[J]. Parasit Vectors, 2013, 6(1): 199.
[27]	Wang J, Zhang C, Wei X, et al. TGF-β and TGF-β/Smad signaling in the interactions between Echinococcus multilocularis and its hosts[J]. PLoS One, 2013, 8(2): e55379.
[28]	Yan C, Wang L, Li B, et al. The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis[J]. Parasit Vectors, 2015, 8: 70.
[29]	Pang N, Zhang F, Ma X, et al. TGF-β/Smad signaling pathway regulates Th17/Treg balance during Echinococcus multilocularis infection[J]. Int Immunopharmacol, 2014, 20(1): 248-257.
[30]	周洋, 金一帮, 王俊华, 等. 细粒棘球蚴囊液对体外培养小鼠脾细胞Foxp3和Smad4基因表达的影响[J]. 中国病原生物学杂志, 2011, 6(3): 193-197.
[31]	Yin S, Chen X, Zhang J, et al. The effect of Echinococcus granulosus on spleen cells and TGF-β expression in the peripheral blood of BALB/c mice[J]. Parasite Immunol, 2017, 39(3): e12415.
[32]	张静, 曾静, 李亮, 等. Smad蛋白抑制剂SIS3对细粒棘球蚴原头节的作用研究[J]. 中国病原生物学杂志, 2017, 12(5): 389-393.
[33]	Hong SK, Wu PK, Park JI.A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses[J]. Cell Signal, 2018, 42: 11-20.
[34]	Androutsopoulos VP, Spandidos DA.Anticancer pyridines induce G2/M arrest and apoptosis via p53 and JNK upregulation in liver and breast cancer cells[J]. Oncol Rep, 2018, 39(2): 519-524.
[35]	Cicenas J, Zalyte E, Rimkus A, ,et al. JNK.JNK, p38,ERK,SGK1 inhibitors in cancer[J]. Cancers (Basel), 2018, 10(1): pii: E1.
[36]	王成华, 吕海龙, 姜玉峰, 等. 棘球蚴MAPK信号转导通路的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2013, 31(1): 60-63.
[37]	Kimata M, Michigami T, Tachikawa K, et al. Signaling of extracellular inorganic phosphate up-regulates cyclin D1 expression in proliferating chondrocytes via the Na+/Pi cotransporter Pit-1 and Raf/MEK/ERK pathway[J]. Bone, 2010, 47(5): 938-947.
[38]	Kawanaka H, Tomikawa M, Baatar D, et al. Despite activation of EGF-receptor-ERK signaling pathway, epithelial proliferation is impaired in portal hypertensive gastric mucosa[J]. Life Sci, 2001, 69(25/26): 3019-3033.
[39]	Patel A, Chojnowski AN, Gaskill K, et al. The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses[J]. Mol Biochem Parasitol, 2011, 176(2): 90-97.
[40]	Cheng Z, Liu F, Li X, et al. EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development[J]. PLoS Negl Trop Dis, 2017, 11(2): e0005418.
[41]	Zhang C, Wang J, Lü G, et al. Hepatocyte proliferation/growth arrest balance in the liver of mice during E. ultilocularis infection: a coordinated 3-stage course[J]. PLoS One, 2012, 7(1): e30127.
[42]	Gelmedin V, Caballero-Gamiz R, Brehm K.Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: antiparasitic activities of p38 MAPK inhibitors[J]. Biochem Pharmacol, 2008, 76(9): 1068-1081.
[43]	Gelmedin V, Spiliotis M, Brehm K.Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis[J]. Int J Parasitol, 2010, 40(5): 555-567.