Research advances on the Toxoplasma gondii toxofilin protein

Abstract

Abstract:

Toxofilin is a member of the Toxoplasma gondii rhoptry protein family with a unique property of lack of a typical serine/threonine kinase domain for rhoptrys. Toxofilin secreted into host cytoplasm can interact with phosphopeptide 2C (PP2C) and actin to form a toxofilin-actin-PP2C trimer complex. Toxofilin is phosphorylated upon activation by casein kinase Ⅱ (CKⅡ) and PP2C, which plays an important role during its invasion. This review summarizes the discovery and research advances on function and immune-protection of toxofilin.

Key words: Toxoplasma gondii, Toxofilin, Actin, Phosphatase 2C, Casein kinase Ⅱ

CLC Number:

R382.5

Gong-zhen LIU, Yuan-jing LIU, Xiang-yun PENG, Jing-xuan KOU. Research advances on the Toxoplasma gondii toxofilin protein[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(2): 174-177.

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