›› 2010, Vol. 28 ›› Issue (5): 9-367.

• 论著 • Previous Articles     Next Articles

Acute infection of Toxoplasma gondii affects the level of oxygen free radicals in serum and testes of mice

YANG Jun-feng1，YUE Hui-ping1，HOU Yu-ying1 *，LIU Zhi-shen2，RAO Hua-xiang3，HE Yan-xia1，ZHANG Ting-ting1，HUANG Chun-yan1，GUO Li-na1   

  1. 1 Institute of Medical Parasitology，Shanxi Medical University，Taiyuan 030001，China；2 General Hospital，Shanxi Jincheng Anthrancite Mining Group，Jincheng 048006，China; 3 Institute for Communicabile Disease Control and Prevention，Qinghai center for Disease Control and Prevention，Xining 810007，China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-10-30 Published:2010-11-09

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Abstract: Objective To observe the impact of Toxoplasma gondii infection on the level of oxygen free radicals and antioxidant enzyme in serum and testes of mice. Methods 40 BALB/c male mice were randomly divided into four groups. Five mice from each group were injected intraperitoneally with 2.5×103 tachyzoites of T. gondii, the others received PBS. Mice were sacrificed on the 1st, 3rd, 5th, and 7th day after inoculation. Samples of serum and testes were collected to determine the content of oxygen free radicals and superoxide dismutase（SOD）. Results The concentration of the oxygen free radicals （NO, ·OH, O2-） in serum and testes of the mice increased along with the days of infection. The concentration of SOD reached a peak on the 3rd day after the injection and then decreased. Both of oxygen free radicals and SOD showed a statistical difference with the control （P＜0.01）. Conclusion Acute infection of T. gondii leads to an increase of oxygen free radicals and SOD in the serum and testes of mice.

Key words: Toxoplasma gondii, Testis, Serum, Oxygen free radical, SOD