›› 2010, Vol. 28 ›› Issue (5): 14-392.

• 综述 • Previous Articles     Next Articles

Progress on the application of Cryptoporidium infected animal models and in vitro cultivation

YIN Jian-hai，SHEN Yu-juan，CAO Jian-ping*   

  1. National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH; WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-10-30 Published:2010-11-09
  • Contact: CAO Jian-ping

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Abstract: The genus Cryptosporidium is composed of protozoan parasites that infect epithelial cells in the microvillus border of the gastrointestinal tract of all classes of vertebrates, and cause severe diarrheal disease in a variety of neonatal animals, children and immunocompromised persons. Establishment of Cryptosporidium infected animal models and its in vitro cultivation system have established a good foundation for characterizing life cycle stage, exploring immunological mechanism, developing vaccines, screening and evaluating potential drugs, as well as assessing oocyst inactivation techniques. This paper reviews recent development and application of the Cryptosporidium infected animal models and its in vitro cultivation.

Key words: Cryptosporidium, Animal model, In vitro cultivation, Application