Abstract: 　Objective] To detect circulating antigen in the patients with schistosomiasis. [Methods] Polyclonal antibody(PcAb) monoclonal antibody(McAb) sandwich ELISA. [Results] Sera from 150 patients with schistosomiasis were detected, the average sensitivity was 84.7%(72.0%～91.0%). No false positive reaction was detected in 40 normal controls and none but 2 patients(2/10) with paragonimiasis showed cross reactions among 74 cases with other parasitic infections. [Conclusion] PcAb McAb sandwich ELISA is a relatively ideal method for circulatling antigen detection.

Key words: Schistosomiasis, circulating antigen detection, sandwich ELISA.