EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII

›› 1999, Vol. 17 ›› Issue (2): 12-108.

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EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII

FANG Yanqiu ¹;TAN Yan ¹;ZHANG Yongsheng²;LI Jing ³

1 Central Lab.;First Teaching Hospital;Bethune University of Medical Sciences;Changchun 130021 2 Department of Parasitology;Bethune University of Medical Sciences;Changchun 130021 3 F

Received:1900-01-01 Revised:1900-01-01 Online:1999-04-30 Published:1999-04-30

Abstract

Abstract: 　AIM: To observe the effect of IL 6 on the multiplication of Toxoplasma gondii.METHODS: Peritoneal macrophages from C57BL/6 mouse were incubated with 3 H uracil labelled T.gondii in vitro . RESULTS: Pretreatment (but not post treatment) of MΦ with IL 6 enhanced T.gondii multiplication in a dose dependent manner. Pretreatment with IFNγ resulted in active killing of parasites whereas the addition of IL 6 resulted in a partial reversal of IFNγ mediated toxoplasmacidal activity. Combining TNFα with IL 6 and IFNγ pretreatment resulted in restoration of toxoplasmacidal activity. Addition of polyclonal anti TNFα antibodies to IL 6 and IFNγ pretreatment resulted in enhancement in the IL 6 mediated impairment of IFNγ function. CONCLUSION: IL 6 could enhance intraperitoneal multiplication of T.gondii and reverse IFNγ mediated toxoplasmacidal activity.

Key words: Toxoplasma gondii, IL 6, IFNγ, TNFα

FANGYanqiu;TANYan;ZHANGYongsheng;LIJing . EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII[J]. , 1999, 17(2): 12-108.

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EFFECT OF IL 6 ON THE MULTIPLICATION OF TOXOPLASMA GONDII

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