Abstract: AIM: To study the effect of praziquantel and mebendazole medicated salt for treating Echinochasmus fujianensis infection. METHOD: 109 cases with E. fujianensis infection were randomly divided into four groups, and administrated respectively with a single dose of praziquantel: 5 mg/kg (A), 2.5 mg/kg (B); or daily dose of mebendazole medicated salt contai ning the drug 80 mg × 10 d (C), 40 mg × 10 d (D). The parameters for evaluating efficacy were egg negative conversion rates and egg reduction rates. RESULTS: Four weeks after treatment, the negative conversion rates were 100%, 92.3%, 85.2% and 71.4% in groups A, B, C and D, respectively; the egg reduction rates were 84.8%-100%. The curative effects among groups A, B and C are not statistically different. CONCLUSION: Praziquantel is the drug of choice for treatment of E. fujianensis, while mebendazole is also effective,especially for those with mixed infections of other intestinal namtodes.