Research progress on the treatment of malaria with artemisinin and its derivatives

doi:10.12140/j.issn.1000-7423.2021.03.016

Abstract

Abstract:

Artemisinin is a safe antimalarial drug. Artemisinin-based drug combinations have been recommended by the World Health Organization as the first-line treatment for falciparum malaria. However, artemisinin resistance is emerging in the treatment of malaria, and has gradually become a major threat to malaria control. Artemisinin drugs have attracted much attention due to the quick effect and low toxicity. In recent years, research and clinical application of artemisinin and its derivatives have been continuously carried out in depth. This paper reviews the antimalarial mechanism, drug resistance phenomenon and mechanism and clinical application of artemisinin drugs, in order to provide valuable reference of further research and application of artemisinin and its derivatives.

Key words: Artemisinin, Artemisinin derivatives, Artemisinin resistance, Malaria

CLC Number:

R531.3

YANG Bo, SUN Yi-fan, LEI Yao, CHENG Yang. Research progress on the treatment of malaria with artemisinin and its derivatives[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(3): 393-402.

Figures/Tables 3

Table 1

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试验药物	试验时间、地点	试验对象	试验结果	参考文献
AS + SP;AL	2009年11月至2013年3月;也门	432名6个月至75岁的恶性疟患者	AS+SP的PCR校正治愈率为98%和100%,AL的PCR校正治愈率均为100%	[59]
PND-AS;DHA + PPQ	2011年10月至2016年2月;西非	4 710名6个月及以上的成人和儿童恶性疟患者	在第28天和第42天,所有研究方法对经PCR调整的人群总有效率均超过99%	[60]
AL;DHA + PPQ	2012年1月至2013年3月;乌干达东部	150名患严重疟疾的儿童	第7天毛细血管哌喹浓度低（<57 ng/ml）的儿童治疗失败的风险是浓度高（> 57 ng/ml）的儿童的两倍;建议在儿童中采用更高剂量的DHA+PPQ	[61]
DHA + PPQ;DHA-PPQ + MQ;AS + MQ;AL;AL + AQ	2015年8月至2018年2月;大湄公河次区域国家及孟加拉国、印度、刚果民主共和国	1 100例2至65岁感染恶性疟原虫者	DHA-PPQ+MQ组在3个地区中第42天的 PCR校正有效率分别为98%、91%、96%;AL+AQ组第42天%）	[63]
MB-As-AQ;PQ-As-AQ	2016年7月至11月;布基纳法索	100名6至59个月的单纯恶性疟患儿	MB组的疟原虫清除率明显更高,配子体密度低于PQ组	[64]
AS + AQ;AL	2017年10月至2018年3月;加蓬兰巴莱市	100名6个月至12岁的儿童	AL和AS+AQ第28天的PCR校正治愈率分别为97%和95%	[62]