Analysis on safety of albendazole in the treatment of echinococcosis

doi:10.12140/j.issn.1000-7423.2020.03.015

Abstract

Abstract:

This study aimed to investigate the probability of adverse effects of albendazole in the treatment of echinococcosis and assess the drug safety, providing reference for its safe medication in clinical practice. Literature search was performed in PubMed, EMBase, China Biology Medicine disc(CBMdisc), China National Knowledge Infrastructure(CNKI) and Wanfang Databases to obtain studies on the use of albendazole in the treatment of echinococcosis. Eligible studies were included according to the inclusion and exclusion criteria, and the reported adverse effects of albendazole were statistically analyzed. This review analyzed 26 eligible studies included, and found that the studies were mostly performed in Xinjiang, while considerably fewer performed in Tibet. According to the literature available, the occurrence rate of severe adverse effects was not high, and the adverse effects often involved digestive system, skin rash, and blood system, with transient presentation in most cases. The data indicates that the studies on the adverse side effects of albendazole is apparently limited. Although the current study results currently available suggest that albendazole is rather safe in clinical use, scale-up clinical trials remain imperative to verify this safety and address the drug safety.

Key words: Echinococcosis, Albendazol, Adverse drug reaction

CLC Number:

R532.32

LIU Ke-xin, ZHANG Wei, JIN Zhao-hui, QIN Zhou, ZHAXI Qun-zong, XU Ting. Analysis on safety of albendazole in the treatment of echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(3): 354-359.

Figures/Tables 3

纳入研究	年份	地区/国家	研究类型	棘球蚴病部位	总例数	男性患者人数	女性患者人数	年龄/中位年龄
张超威^[12]	1990	N	临床观察	棘球蚴（肝、肺、腹膜、其他）	253	N	N	N
李明^[13]	1991	宁夏	对照实验	肝多房棘球蚴	80	20	60	17~71
Khuroo^[14]	1993	印度	随机对照	肝棘球蚴	20	7	13	12~64
Gil-Grande^[15]	1993	西班牙	随机对照	肝棘球蚴	37	22	15	N
李富荣^[16]	1996	兰州	临床观察	棘球蚴（肝、肺、腹膜、其他）	102	54	48	8~77
Franchi^[17]	1999	意大利	随机对照	肝棘球蚴	323	N	N	N
张贺玲^[18]	2000	新疆	临床观察	细粒棘球蚴	61	N	N	6~73
柴君杰^[19]	2001	新疆	临床观察	肝细粒棘球蚴	212	114	98	4~82
柯山^[20]	2002	新疆	对照实验	棘球蚴	53	27	26	N
亚德卡尔^[21]	2002	新疆	临床观察	肝细粒棘球蚴	71	37	34	7~70
李海涛^[22]	2004	新疆	临床观察	棘球蚴	66	35	31	8~76
Chai^[23]	2004	新疆	对照实验	肝棘球蚴	264	138	126	4~82
Bildik^[24]	2007	土耳其	随机对照	肝棘球蚴	63	N	N	N
李海涛^[25]	2010	新疆	临床观察	肝多房棘球蚴	26	10	16	14~67
朱兵^[26]	2010	新疆	临床观察	肝棘球蚴	24	15	9	15~60
Salinas^[27]	2011	秘鲁	回顾性	肝棘球蚴	27	7	20	51 ± 14
Shams^[28]	2011	印度	随机对照	肝棘球蚴	36	20	16	37 ± 12
古丽拜尔^[29]	2012	新疆	临床观察	肝细粒棘球蚴	116	54	52	N
王立英^[30]	2014	青海	临床观察	棘球蚴	160	70	110	6-16
Karabulut^[31]	2014	土耳其	回顾性	肝棘球蚴	101	38	62	47 ± 16
陈辉^[32]	2015	西藏	回顾性	脑棘球蚴 + 脑囊虫	22	15	7	26~58
Moroni^[33]	2016	美国	回顾性	棘球蚴	28	12	16	9 ± 4
Saidi^[34]	2018	伊朗	回顾性	肝棘球蚴	127	N	N	N
Fattahi^[35]	2018	伊朗	回顾性	多房棘球蚴	119	44	75	38
陈文君^[36]	2019	青海	临床观察	脑多房棘球蚴	18	10	8	21~59
Shankar^[37]	2019	印度	回顾性	棘球蚴（肝、肺）	22	15	7	13

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