多房棘球蚴病的免疫逃避机制

摘要/Abstract

摘要：

多房棘球蚴病是一种人兽共患寄生虫病,呈世界性分布,严重危害着人类健康和畜牧业的发展。近年来,多房棘球蚴病免疫逃逸机制成为研究热点。本文主要从改变自身抗原、细胞毒作用、负向调节免疫、改变免疫反应类型、诱导免疫细胞凋亡、免疫抑制作用及宿主的先天免疫及遗传背景等方面综述多房棘球蚴逃避宿主免疫防御攻击机制,为抗击棘球蚴病提供新的临床免疫诊疗思路。

关键词: 多房棘球蚴病, 免疫逃避, 机制

Abstract:

Alveolar echinococcosis （AE） is a zoonotic parasitic disease that has a worldwide distribution and seriously threatens human health and husbandry. In recent years, the immune escape mechanism of AE has become a research hotspot. This review is focused on the immune escape mechanisms from perspectives of self-antigen alteration, cytotoxicity, negative immune regulation, alteration of types of immune response, induction of immune cell apoptosis, immunosuppression, and innate immunity and genetic background of the host, in order to provide novel insights into echinococcosis.

Key words: Alveolar echinococcosis, Immune evasion, Mechanism

中图分类号:

R532.32

刘寒冬, 王宏宾, 樊海宁, 牛海峰, 王志鑫. 多房棘球蚴病的免疫逃避机制[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(6): 655-660.

Han-dong LIU, Hong-bing WANG, Hai-ning FAN, Hai-feng NIU, Zhi-xin WANG. Alveolar echinococcosis and immune evasion[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(6): 655-660.

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