Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展

doi:10.12140/j.issn.1000-7423.2025.01.019

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (1): 124-128.doi: 10.12140/j.issn.1000-7423.2025.01.019

Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展

周檀芳()(), 朱江, 徐心路, 祖力皮喀尔·图孙尼亚孜, 卡力比夏提·艾木拉江, 温浩^*()()

省部共建中亚高发病成因与防治国家重点实验室，新疆医科大学第一附属医院，临床医学研究院，新疆乌鲁木齐 830000

收稿日期:2024-10-19 修回日期:2024-12-01 出版日期:2025-02-28 发布日期:2025-03-26
通讯作者: *温浩（ORCID：0000-0001-7144-220X），男，主任医师，教授，从事肝胆外科研究。E-mail：dr.wenhao@163.com
作者简介:周檀芳（ORCID：0009-0002-8084-8329），女，硕士研究生，从事肝棘球蚴病研究。E-mail：fangtan1105@163.com
基金资助:
天山英才项目(2023TSYCQNTJ0045);新疆维吾尔自治区重点研发项目(2022B03013-3)

Research progress on Toll-like receptors-mediated host immune responses in echinococcosis

ZHOU Tanfang()(), ZHU Jiang, XU Xinlu, ZULIPIKAER Tuersunniyazi, KALIBIXIATI Aimulajiang, WEN Hao^*()()

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang, China

Received:2024-10-19 Revised:2024-12-01 Online:2025-02-28 Published:2025-03-26
Contact: *E-mail: dr.wenhao@163.com
Supported by:
Tianshan Young Talents Project(2023TSYCQNTJ0045);Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B03013-3)

摘要/Abstract

摘要：

棘球蚴病是由棘球绦虫幼虫感染引起的人兽共患寄生虫病。棘球蚴感染能够调节宿主的免疫应答，并改变宿主的免疫微环境，从而引发免疫和炎症反应。Toll样受体（TLR）作为一类模式识别受体，能够有效识别病原体相关分子模式。通过调控TLR表达与功能，可激活下游信号传导途径，这在棘球蚴病的宿主免疫应答中起重要作用。本文综述了TLR尤其是TLR2和TLR4在棘球蚴病研究中的最新进展，并探讨其在未来治疗中的潜在应用，旨在为棘球蚴病的预防和治疗提供新的思路。

关键词: 肝棘球蚴病, Toll样受体, Toll样受体2, Toll样受体4, 免疫

Abstract:

Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus species. Echinococcus infection may modulate host immune response and alter host immune microenvironments, thereby triggering immune and inflammatory responses. As a pattern recognition receptor, Toll-like receptors (TLRs) may effectively recognize pathogen-associated molecular patterns and activate downstream signaling pathways by regulating TLR expression and functions, which play an important role in host immune responses to echinococcosis. This review summarizes the latest progress of TLRs in echinococcosis research, with a special emphasis on TLR2 and TLR4, and discusses their potential applications in future treatments of echinococcosis, so as to provide new insights into for echinococcosis prevention and treatment.

Key words: Hepatic echinococcosis, Toll-like receptor, Toll-like receptor 2, Toll-like receptor 4, Immunity

中图分类号:

R532.32

周檀芳, 朱江, 徐心路, 祖力皮喀尔·图孙尼亚孜, 卡力比夏提·艾木拉江, 温浩. Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(1): 124-128.

ZHOU Tanfang, ZHU Jiang, XU Xinlu, ZULIPIKAER Tuersunniyazi, KALIBIXIATI Aimulajiang, WEN Hao. Research progress on Toll-like receptors-mediated host immune responses in echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(1): 124-128.

图/表 1

参考文献 44

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Toll样受体介导的宿主免疫应答在棘球蚴病中的研究进展

Research progress on Toll-like receptors-mediated host immune responses in echinococcosis

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