白蛉携带病原体及其肠道微生物的研究进展

doi:10.12140/j.issn.1000-7423.2025.01.020

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (1): 129-134.doi: 10.12140/j.issn.1000-7423.2025.01.020

白蛉携带病原体及其肠道微生物的研究进展

崔蕾¹(), 方圆¹^,², 周正斌¹, 何雅琦¹, 张仪¹^,²^,^*()()

1 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）；传染病溯源预警与智能决策全国重点实验室；国家卫生健康委员会寄生虫病原与媒介生物学重点实验室；世界卫生组织热带病合作中心；科技部国家级热带病国际联合研究中心，上海 200025
2 上海交通大学医学院国家热带病研究中心全球健康学院，上海 200025

收稿日期:2024-09-18 修回日期:2024-12-06 出版日期:2025-02-28 发布日期:2025-03-26
通讯作者: *张仪（ORCID：0000-0002-3169-1823），女，硕士，研究员，从事寄生虫与媒介的研究。E-mail：zhangyi@nipd.chinacdc.cn
作者简介:崔蕾，女，硕士研究生，从事医学媒介生物防制的研究。E-mail：2264677077@qq.com
基金资助:
国家重点研发计划(2023YFA1801000);国家重点研发计划(2023YFA1801001);国家自然科学基金(32161143036)

Research progress on pathogens carried by sand flies and their gut microbiota

CUI Lei¹(), FANG Yuan¹^,², ZHOU Zhengbin¹, HE Yaqi¹, ZHANG Yi¹^,²^,^*()()

1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory on Parasite and Vector Biology, National Health Commission; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
2 School of Global Health, National Center for Tropical Disease Research, Shanghai Jiao Tong University, Shanghai 200025, China

Received:2024-09-18 Revised:2024-12-06 Online:2025-02-28 Published:2025-03-26
Contact: *E-mail: zhangyi@nipd.chinacdc.cn
Supported by:
National Key Research and Development Program of China(2023YFA1801000);National Key Research and Development Program of China(2023YFA1801001);National Natural Science Foundation of China(32161143036)

摘要/Abstract

摘要：

白蛉作为多种病原体的传播媒介具有重要的流行病学意义。白蛉肠道内定植着大量的微生物群落，对白蛉及其携带病原体的繁殖和生长发育有着重要影响。本文综述了白蛉携带病原体的种类和肠道微生物的组成，并揭示了白蛉-病原体-肠道微生物之间的相互关系。肠道微生物不仅能直接抑制病原体的感染和传播，也可通过参与白蛉的免疫应答和防御机制，间接改变其感染和传播病原体的能力。

关键词: 白蛉, 病原体, 肠道微生物

Abstract:

As a vector of multiple pathogens, sand flies have important epidemiological significance. A large number of microbial communities are colonized in the gut of sand flies, which pose a significant impact on the reproduction, growth and development of sand flies and sand flies-borne pathogens. The review summarizes the species of pathogens carried by sand flies and the composition of gut microbiota, and unravel the interactions among sand flies, pathogens, and gut microbiota. Gut microbiota not only directly inhibits the infection and transmission of pathogens, but also indirectly alters the ability of pathogen infections and transmission by sand flies through participation in the immune responses and defense mechanisms of sand flies.

Key words: Sand fly, Pathogen, Gut microbiota

中图分类号:

R384.1

崔蕾, 方圆, 周正斌, 何雅琦, 张仪. 白蛉携带病原体及其肠道微生物的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(1): 129-134.

CUI Lei, FANG Yuan, ZHOU Zhengbin, HE Yaqi, ZHANG Yi. Research progress on pathogens carried by sand flies and their gut microbiota[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(1): 129-134.

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白蛉携带病原体及其肠道微生物的研究进展

Research progress on pathogens carried by sand flies and their gut microbiota

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