巨噬细胞调控多房棘球蚴病所致肝纤维化研究进展

doi:10.12140/j.issn.1000-7423.2024.06.015

中国寄生虫学与寄生虫病杂志 ›› 2024, Vol. 42 ›› Issue (6): 790-795.doi: 10.12140/j.issn.1000-7423.2024.06.015

巨噬细胞调控多房棘球蚴病所致肝纤维化研究进展

尹先敏¹(), 种世桂¹^,², 陈根¹, 秦俊梅¹, 赵玉敏¹^,²^,^*()

1 桂林医学院基础医学院人体寄生虫学教研室，广西桂林 541199
2 甘肃医学院，甘肃平凉 744099

收稿日期:2024-05-28 修回日期:2024-09-26 出版日期:2024-12-30 发布日期:2025-01-14
通讯作者: *赵玉敏（1971—），男，博士，教授，主要从事寄生虫病防治研究。E-mail：zymcsg@sina.com
作者简介:尹先敏（1998—），女，硕士研究生，主要从事寄生虫病防治研究。E-mail：yinxianmin2022@163.com
基金资助:
国家自然基金地区项目(82460403);甘肃省高等学校产业支撑计划项目(2022CYZC-72)

Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis

YIN Xianmin¹(), CHONG Shigui¹^,², CHEN Gen¹, QIN Junmei¹, ZHAO Yumin¹^,²^,^*()

1 Department of Parasitology, School of Basic Medical Sciences, Guilin Medical University, Guilin 541199, Guangxi, China
2 Gansu Medical Colledge, Pingliang 744099, Gansu, China

Received:2024-05-28 Revised:2024-09-26 Online:2024-12-30 Published:2025-01-14
Contact: *E-mail: zymcsg@sina.com
Supported by:
National Natural Science Foundation of China(82460403);Industrial Support Program Project for Colleges and Universities in Gansu Province(2022CYZC-72)

摘要/Abstract

摘要：

多房棘球蚴病（AE）是一种严重危害人类健康和畜牧业发展的人兽共患寄生虫病。AE病变周围各种免疫细胞（包括巨噬细胞）浸润增加，可造成以肝脏为主的多种重要器官纤维化，并可能发展成肝硬化和肝癌等严重疾病。几种巨噬细胞在AE肝脏炎症的进程以及纤维化形成的不同时期分别表现为M1型巨噬细胞或M2型巨噬细胞,并分泌促炎细胞因子和抗炎细胞因子,以此来促进早期棘球蚴的清除作用和中晚期的抗炎作用从而在AE肝脏纤维化的形成过程中发挥调控作用。本文从AE所致肝脏纤维化中几种巨噬细胞的调控机制作一论述。

关键词: 多房棘球蚴病, 巨噬细胞, 肝脏纤维化

Abstract:

Alveolar echinococcosis (AE) is a zoonotic parasitic disease that poses a serious threat to human health and the development of animal husbandry. The augmented infiltration of various immune cells (including macrophages) around AE lesions can lead to fibrosis in various important organs, primarily the liver, and might progress into cirrhosis, liver cancer, and other serious disorders. Several types of macrophages manifest as M1 or M2 macrophages at different stages of AE liver inflammation and fibrosis formation, secreting pro-inflammatory and anti-inflammatory cytokines to promote the clearance of echinococcus in the early stage and exerting an anti-inflammatory effect in the middle and late stages, thereby playing a regulatory role in AE liver fibrosis formation. In this article, the regulatory mechanisms of several types of macrophages in AE-induced liver fibrosis are discussed.

Key words: Alveolar Echinococcosis, Macrophage, Liver Fibrosis

中图分类号:

R532.32

尹先敏, 种世桂, 陈根, 秦俊梅, 赵玉敏. 巨噬细胞调控多房棘球蚴病所致肝纤维化研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(6): 790-795.

YIN Xianmin, CHONG Shigui, CHEN Gen, QIN Junmei, ZHAO Yumin. Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(6): 790-795.

图/表 1

参考文献 52

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巨噬细胞调控多房棘球蚴病所致肝纤维化研究进展

Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis

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