miRNA在寄生虫宿主免疫调控中的研究进展

中国寄生虫学与寄生虫病杂志 ›› 2018, Vol. 36 ›› Issue (4): 405-408.

miRNA在寄生虫宿主免疫调控中的研究进展

刘可, 黄海斌, 杨桂连^*()

吉林农业大学动物科学技术学院,吉林省动物微生态制剂工程研究中心,长春 130118

收稿日期:2017-11-09 出版日期:2018-08-30 发布日期:2018-09-06
通讯作者: 杨桂连
基金资助:
国家重点研发计划（No. 2017YFD0501200）;国家863计划（No. 2013AA102806）;国家自然科学基金（No. 31272552）;吉林省科技发展计划（No. 20160519011JH, No. 20170204034NY）;吉林省产业创新专项资金（No. 2016C063）

miRNA functions in parasite-related immune regulation in hosts

Ke LIU, Hai-bin HUANG, Gui-lian YANG^*()

College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics,Jilin Agricultural University, Changchun 130118, China

Received:2017-11-09 Online:2018-08-30 Published:2018-09-06
Contact: Gui-lian YANG
Supported by:
Supported by the National Key Research and Development Project (No. 2017YFD0501200), the National 863 Project (No. 2013AA102806), the National Natural Science Foundation of China (No. 31272552), Jilin Provincial Science and Technology Development Project (No. 20160519011JH, No. 20170204034NY), and Jilin Provincial Industrial Innovation Special Fund Project (No. 2016C063)

摘要/Abstract

摘要：

微小RNA（miRNA）是一种内源性小分子RNA,其通过转录后具有调控基因的功能,参与生理和病理过程的调控。目前,miRNA在寄生虫同宿主相互作用中的功能探索成为研究热点,包括寄生虫产生miRNA的传播方式、调控免疫应答反应、在中间宿主中的调控作用,以及其调控寄生虫感染的免疫病理学作用等。本文对上述研究进展进行了综述,以期为寄生虫致病机制的深入研究提供思路。

关键词: 寄生虫, miRNA, 免疫调控

Abstract:

MicroRNAs (miRNAs) are endogenous small-molecule RNAs that participate in the regulation of physiological and pathological processes through post-transcriptional regulation of gene expression. Exploring the functions of miRNAs in host-parasite interactions has become a research focus these years, with topics including the transmission of miRNAs from parasites, the miRNA-mediated regulation of host immune responses, the intermediate host responses, and the immunopathological effects induced by parasite infection. In this review we summarize the latest studies on these topics in order to provide new insights for further research on pathogenesis mechanisms of the parasites.

Key words: Parasite, miRNA, Immune regulation

中图分类号:

刘可, 黄海斌, 杨桂连. miRNA在寄生虫宿主免疫调控中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(4): 405-408.

Ke LIU, Hai-bin HUANG, Gui-lian YANG. miRNA functions in parasite-related immune regulation in hosts[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(4): 405-408.

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