DETECTING CIRCULATING ANTIGEN IN PATIENTS OF CHRONIC SCHISTOSOMIASIS USING STAPHYLOCOCCUS PROTEIN A CO AGGLUTINATION TEST

Abstract

Abstract: AIM: To determine the sensitivity, specificity and efficacy evaluation capacity of the staphylococcus protein A co agglutination test(SPA CoA) in detecting circulating antigens in the patients of chronic schistosomiasis.METHOD: Sera from 72 chronic schistosomiasis patients were examined before and after treatment. RESULTS: A positive rate of 93.1%(67/72)was achieved in chronic cases before treatment.No significant correlations were found between EPG and the antigen titres(r=0.0256, P 0.05).In healthy controls,3 out of 95 were positive,accounting for a false positive rate of 3.2%.For cross reactions,only 1 out of 10 clonorchiasis patients was positive and none was found positive in 11 non parasitic di sease controls .Three months after treatment,80.7%(46/57)of the patients followed up with negative fecal examinations showed negative conversion in serum antigen detections.All the patients remained fecal egg positive still showed SPA CoA positive,but the antigen titers were much reduced than those before treatment. CONCLUSION: With simplicity,rapidity and low cost,SPA CoA is recommended to be used in the diagnosis of schistosomiasis as well as in the evaluation of therapeutic efficacy.

CLC Number:

R532.21

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DETECTING CIRCULATING ANTIGEN IN PATIENTS OF CHRONIC SCHISTOSOMIASIS USING STAPHYLOCOCCUS PROTEIN A CO AGGLUTINATION TEST

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