Abstract: In recent years, gold nanoparticles（GNPs） have attracted more and more attention for their unique physical, chemical and biological properties, and are emerging as optical probes and biocompatibility materials for use. With the application of nanogold labeling technology in the medical field, detection techniques using GNPs as immune markers will become a major labeling technique, and will have wide applications in basic and clinical medicine. In this article, recent research progress on the applications of GNPs in the detection of pathogens, nucleic acids, and proteins and in the preparation of biosensors is reviewed.

Key words: Gold nanoparticle, Labeling technique, Detection