Research progress on Toll-like receptors-mediated host immune responses in echinococcosis

doi:10.12140/j.issn.1000-7423.2025.01.019

Abstract

Abstract:

Echinococcosis is a zoonotic parasitic disease caused by the larval stage of Echinococcus species. Echinococcus infection may modulate host immune response and alter host immune microenvironments, thereby triggering immune and inflammatory responses. As a pattern recognition receptor, Toll-like receptors (TLRs) may effectively recognize pathogen-associated molecular patterns and activate downstream signaling pathways by regulating TLR expression and functions, which play an important role in host immune responses to echinococcosis. This review summarizes the latest progress of TLRs in echinococcosis research, with a special emphasis on TLR2 and TLR4, and discusses their potential applications in future treatments of echinococcosis, so as to provide new insights into for echinococcosis prevention and treatment.

Key words: Hepatic echinococcosis, Toll-like receptor, Toll-like receptor 2, Toll-like receptor 4, Immunity

CLC Number:

R532.32

ZHOU Tanfang, ZHU Jiang, XU Xinlu, ZULIPIKAER Tuersunniyazi, KALIBIXIATI Aimulajiang, WEN Hao. Research progress on Toll-like receptors-mediated host immune responses in echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(1): 124-128.

Figures/Tables 1

References 44

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