CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2024, Vol. 42 ›› Issue (2): 259-266.doi: 10.12140/j.issn.1000-7423.2024.02.018

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Research on the progress of programmed cell death in echinococcosis

DAWA Zhuoma1,2(), LIU Chuanchuan2,3, FAN Haining2,3,*()   

  1. 1 Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
    2 Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China
    3 Qinghai University Affiliated Hospital, Xining 810000, China
  • Received:2023-12-07 Revised:2024-01-28 Online:2024-04-30 Published:2024-04-25
  • Contact: * E-mail: fanhaining@medmail.com.cn
  • Supported by:
    Province Natural Science Foundation of Qinghai(2023-ZJ-992Q)

Abstract:

Echinococcosis is a serious zoonosis disease caused by the metacestode stage larval of Echinococcus granulosus and E. mulculoris. Humans as an intermediate host infected by the larvae stages of the parasites through accidental ingestion of the eggs. Programmed cell death is common in the growth and development of Echinococcus. Programmed cell death includes apoptosis, pyroptpsis, autophagy and ferroptosis. In this review, we summarized the role of programmed cell death pathways in the echinococcosis and try to provide a basic theoryto explore potential targets for the prevention and treatment of echinococcosis.

Key words: Echinococcus mulculoris, E. granulosus, Programmed cell death, Apoptosis, Pyroptpsis, Autophagy, Ferroptosis

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