Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis

doi:10.12140/j.issn.1000-7423.2021.02.020

Abstract

Abstract:

Alveolar echinococcosis is a disease caused by infection of Echinococcus multilocularis metacestode, which leads to severe clinical symptoms with high mortality. This disease develops from the host liver, damaging hepatocytes. E. multilocularis metacestode infection could affect the expression of hepatocyte collagen gene, cell cycle alteration, mediation of host immune responses, activation of signaling pathways and expression of related genes. This paper reviews the mechanisms damaging the host hepatocytes to provide useful reference information for treatment of alveolar echinococcosis.

Key words: Alveolar echinococcosis, Echinococcus multilocularis, Hepatocyte damage

CLC Number:

R532.32

XU Kai, WANG Hai-jiu, ZHANG Li, ZHANG Yao-gang, FAN Hai-ning, REN Li, REN Bin, WANG Zhi-xin. Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(2): 256-259.

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