Research progress on new formulations of albendazole against echinococcosis

doi:10.12140/j.issn.1000-7423.2020.03.020

Abstract

Abstract:

Albendazole is the first-option drug for treatment of echinococcosis, with various new formulations including solid dispersion, liposomes, self-microemulsifying, precursor micelles, microspheres and nanodrug. Albendazole liposome formulations have been studied earlier, with its preparation technique being matured, and the formulation have commenced clinical application, however, the shortcomings in carrier modification and drug storage are being improved. Albendazole nanoformulation has wide application prospect, and the reaches in this regard have been growing year by year. Other new formulations of albendazole remain at the laboratory study stage. To be noted, some new albendazole formulations can largely improve the targeting property and bioavailability of the crude drug, and thus expectedly, the new formulations could play important role in reducing adverse effects and improving the bioavailability and therapeutic efficacy of the original crude drug. This review summarizes the researches in recent 10 years on new formulations of albendazole.

Key words: Albendazole, Echinococcosis, Solid dispersion, Liposomes, Self-microemulsifying formulation, Precursor micelles, Microspheres, Nanomedicine

CLC Number:

R532.32

YANG Lin-chuan, TIAN Yi-jiang, ZENG Zhu-lin, ZENG Ren-quan. Research progress on new formulations of albendazole against echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020, 38(3): 383-389.

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