Research progress on the experimental treatment of Echinococcus infection by using Chinese traditional medicine

doi:10.12140/j.issn.1000-7423.2021.05.021

Abstract

Abstract:

Hydatid disease is a zoonotic infectious disease that seriously endangers the health of humans and animals, affecting the development of animal husbandry and public health. At present, the use or combined use of Chinese medicine for the treatment of hydatid disease is receiving much attention. This article reviews the latest research progress in and the advancing direction of Chinese traditional medicine and its combination therapy for hydatid disease, in order to provide reference for the treatment of human hydatid disease and the research and development of new drugs.

Key words: Hydatidosis, Echinococcus, Traditional Chinese medicine, Research progress

CLC Number:

R532.32

XU Kai, HUANG Lu-lu, WU Chuan-ling, LI Wen-deng, YIN Feng-jiao, WANG Zhi-xin, FAN Hai-ning, WANG Hai-jiu. Research progress on the experimental treatment of Echinococcus infection by using Chinese traditional medicine[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(5): 710-715.

References 47

[1]	Khoronko Y, Ermakova L, Pshenichnaya N, et al. The first case of autochthonous Echinococcus multilocularis in human in the Republic of Kalmykia[J]. Int J Infect Dis, 2019, 79:89.
[2]	Wu WP, Wang H, Wang Q, et al. A nationwide sampling survey on echinococcosis in China during 2012—2016[J]. Chin J Parasitol Parasit Dis, 2018, 36(1):1-14.
	( 伍卫平, 王虎, 王谦, 等. 2012—2016年中国棘球蚴病抽样调查分析[J]. 中国寄生虫学与寄生虫杂志, 2018, 36(1):1-14.)
[3]	Xu K, Wang HJ, Zhang L, et al. Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis[J]. Chin J Parasitol Parasit Dis, 2021, 39(2):256-260. (in Chinese)
	( 徐凯, 王海久, 张丽, 等. 多房棘球蚴对宿主肝细胞损害机制的研究进展[J]. 中国寄生虫学与寄生虫杂志, 2021, 39(2):256-260.)
[4]	Zhou SY, Li RT. Advances in studies on chemical constituents and biological activities of Rhododendron[J]. Yunnan J Tradit Chin Med Mater Med, 2008, 29(5):51-53. (in Chinese)
	( 周三云, 李蓉涛. 杜鹃花属植物化学成分及生物活性研究进展[J]. 云南中医中药杂志, 2008, 29(5):51-53.)
[5]	Gao Y, Hao BC, Song XD, et al. Effect of Rhododendron mucronatum decoction against protoscolex in vitro and alveolar hydatids in vivo[J]. Chin Vet Sci, 2019, 49(10):1331-1339. (in Chinese)
	( 高艳, 郝宝成, 宋向东, 等. 白花杜鹃水提液对多房棘球蚴的体外杀灭和体内感染疗效的研究[J]. 中国兽医科学, 2019, 49(10):1331-1339.)
[6]	Luosang DW, Liu WL, Yang BL, et al. Curative effect observation of Tibetan medicine Jiumei No.2 against mice secondary echinococcosis in mice[J]. Chin High Alt Med Biol, 2018, 39(3):197-202. (in Chinese)
	( 洛桑达哇, 刘文磊, 杨宝良, 等. 藏药久美2号对抗小鼠继发性多房棘球蚴病的疗效研究[J]. 中国高原医学与生物学杂志, 2018, 39(3):197-202.)
[7]	Sharma V, Singh I, Chaudhary P. Acorus calamus (The Healing Plant): a review on its medicinal potential, micropropagation and conservation[J]. Nat Prod Res, 2014, 28(18):1454-1466. doi: 10.1080/14786419.2014.915827 pmid: 24824923
[8]	Zheng J, Li ZQ, Yang QY, et al. Study on the β-asarone against Echinococcus multilocularis protoscoleces in vitro[J]. Chin High Alt Med Biol, 2019, 40(4):256-259. (in Chinese)
	( 郑佳, 李占强, 杨全余, 等. β-细辛醚对多房棘球蚴的体外杀伤作用[J]. 中国高原医学与生物学杂志, 2019, 40(4):256-259.)
[9]	Li ZQ, Li RL, Su SS, et al. Study on the lethal activity of essential oil from Acorus calamus L. against protoscoleces in vitro[J]. Chin High Alt Med Biol, 2020, 41(3):188-191. (in Chinese)
	( 李占强, 李润乐, 苏姗姗, 等. 藏菖蒲挥发油对多房棘球蚴的体外杀伤活性[J]. 中国高原医学与生物学杂志, 2020, 41(3):188-191.)
[10]	Liang H, Deng JB, Tong SS, et al. Research progress on the systemic relationship of Curcuma plants in China[J]. Mol Plant Breeding, 2019, 17(11):3695-3702. (in Chinese)
	( 梁恒, 邓家彬, 童珊珊, 等. 我国姜黄属植物的系统关系研究进展[J]. 分子植物育种, 2019, 17(11):3695-3702.)
[11]	Almalki E, Al-Shaebi EM, Al-Quarishy S, et al. In vitro effectiveness of Curcuma longa and Zingiber officinale extracts on Echinococcus protoscoleces[J]. Saudi J Biol Sci, 2017, 24(1):90-94. doi: 10.1016/j.sjbs.2016.05.007 pmid: 28053576
[12]	Mahmoudvand H, Pakravanan M, Kheirandish F, et al. Efficacy and safety Curcuma zadoaria L. to inactivate the hydatid cyst protoscoleces[J]. Curr Clin Pharmacol, 2020, 15(1):64-71. doi: 10.2174/1574884714666190918155147 pmid: 31533603
[13]	Sun W, Zhang XX, Zhou WB, et al. Osthole attenuates LPS-induced inflammatory response in Caco2 cells[J]. J Nanjing Med Univ(Nat Sci), 2017, 37(7):814-817. (in Chinese)
	( 孙武, 张欣欣, 周文博, 等. 蛇床子素抑制LPS诱导的肠上皮细胞株Caco2的炎症反应[J]. 南京医科大学学报(自然科学版), 2017, 37(7):814-817.)
[14]	Li HZ, Wang YH, Fang SB, et al. Experimental research of cnidium lactone micro-emulsion on the anti-inflammatory effect[J]. World J Integr Tradit West Med, 2015, 10(8):1077-1078, 1082. (in Chinese)
	( 李浩铮, 王永辉, 房树标, 等. 蛇床子素微乳抗炎作用的实验研究[J]. 世界中西医结合杂志, 2015, 10(8):1077-1078, 1082.)
[15]	Zhu X, Song X, Xie K, et al. Osthole induces apoptosis and suppresses proliferation via the PI3K/Akt pathway in intrahepatic cholangiocarcinoma[J]. Int J Mol Med, 2017, 40(4):1143-1151. doi: 10.3892/ijmm.2017.3113
[16]	Yuan M, Luo Y, Xin Q, et al. Efficacy of osthole for Echinococcus granulosus in vitro and Echinococcus multilocularis in vivo[J]. Vet Parasitol, 2016, 226:38-43. doi: 10.1016/j.vetpar.2016.05.016
[17]	Wang B, Jiang Y, Wang Z, et al. Arsenic trioxide negatively affects Echinococcus granulosus[J]. Antimicrob Agents Chemother, 2015, 59(11):6946-6951. doi: 10.1128/AAC.04340-14 pmid: 26324279
[18]	Li J, Tang G, Qin W, et al. Toxic effects of arsenic trioxide on Echinococcus granulosus protoscoleces through ROS production, and Ca ²+-ER stress-dependent apoptosis[J]. Acta Biochim Biophys Sin (Shanghai), 2018, 50(6):579-585. doi: 10.1093/abbs/gmy041
[19]	Chen L, Yu YB, Xu Y, et al. In vitro effects of realgar on the growth and antioxidant enzyme activity of Echinococcus granulosus protoscoleces[J]. J Pathog Biol, 2021, 16(1):58-63. (in Chinese)
	( 陈琳, 于云宝, 许雅, 等. 雄黄对细粒棘球蚴原头节体外生长及抗氧化酶活性的影响[J]. 中国病原生物学杂志, 2021, 16(1):58-63.)
[20]	Mohammadhosseini M, Venditti A, Sarker SD, et al. The genus Ferula: Ethnobotany, phytochemistry and bioactivities--a review[J]. Ind Crop Prod, 2019, 129:350-394. doi: 10.1016/j.indcrop.2018.12.012
[21]	Salehi M, Naghavi MR, Bahmankar M. A review of Ferula species: biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists[J]. Ind Crop Prod, 2019, 139:111511. doi: 10.1016/j.indcrop.2019.111511
[22]	Alyousif MS, Al-Abodi HR, Almohammed H, et al. Chemical composition, apoptotic activity, and antiparasitic effects of Ferula macrecolea essential oil against Echinococcus granulosus protoscoleces[J]. Molecules, 2021, 26(4):888. doi: 10.3390/molecules26040888
[23]	Wong YK, Xu C, Kalesh KA, et al. Artemisinin as an anticancer drug: recent advances in target profiling and mechanisms of action[J]. Med Res Rev, 2017, 37(6):1492-1517. doi: 10.1002/med.2017.37.issue-6
[24]	Wen L, Lv G, Zhao J, et al. In vitro and in vivo effects of artesunate on Echinococcus granulosus protoscoleces and metacestodes[J]. Drug Des Devel Ther, 2020, 14:4685-4694. doi: 10.2147/DDDT.S254166
[25]	Ding Y, Xu J, Cheng LB, et al. Effect of emodin on coxsackievirus B3m-mediated encephalitis in hand, foot, and mouth disease by inhibiting toll-like receptor 3 pathway in vitro and in vivo[J]. J Infect Dis, 2020, 222(3):443-455. doi: 10.1093/infdis/jiaa093 pmid: 32115640
[26]	Wang Z, Chen H, Chen J, et al. Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway[J]. Cancer Manag Res, 2019, 11:8463-8473. doi: 10.2147/CMAR
[27]	Xia S, Ni Y, Zhou Q, et al. Emodin attenuates severe acute pancreatitis via antioxidant and anti-inflammatory activity[J]. Inflammation, 2019, 42(6):2129-2138. doi: 10.1007/s10753-019-01077-z
[28]	Mahmoudvand H, Saki M, Kiani AA, et al. In vitro and ex vivo antiparasitic effect of Rheum ribes L. extract against the hydatid cyst protoscoleces[J]. Infect Disord Drug Targets, 2020.(E-pub Ahead of Print)
[29]	Denkova-Kostova R, Teneva D, Tomova T, et al. Chemical composition, antioxidant and antimicrobial activity of essential oils from tangerine (Citrus reticulata L.), grapefruit (Citrus paradisi L.), lemon (Citrus lemon L.) and cinnamon (Cinnamomum zeylanicum Blume)[J]. Z Naturforsch C J Biosci, 2021, 76(5/6):175-185.
[30]	Dorri M, Hashemitabar S, Hosseinzadeh H. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review[J]. Drug Chem Toxicol, 2018, 41(3):338-351. doi: 10.1080/01480545.2017.1417995
[31]	Hamidpour R, Hamidpour M, Hamidpour S, et al. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities[J]. J Tradit Complement Med, 2015, 5(2):66-70. doi: 10.1016/j.jtcme.2014.11.008 pmid: 26151013
[32]	Fabbri J, Maggiore MA, Pensel PE, et al. In vitro efficacy study of Cinnamomum zeylanicum essential oil and cinnamaldehyde against the larval stage of Echinococcus granulosus[J]. Exp Parasitol, 2020, 214:107904. doi: S0014-4894(19)30378-9 pmid: 32371061
[33]	Song YN, Wang Y, Zheng YH, et al. Crocins: a comprehensive review of structural characteristics, pharmacokinetics and therapeutic effects[J]. Fitoterapia, 2021, 153:104969. doi: 10.1016/j.fitote.2021.104969
[34]	Liu C, Fan H, Guan L, et al. In vivo and in vitro efficacy of crocin against Echinococcus multilocularis[J]. Parasit Vectors, 2021, 14(1):364. doi: 10.1186/s13071-021-04866-4
[35]	Jung H, Medina L, García L, et al. Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide[J]. J Pharm Pharmacol, 1998, 50(1):43-48. pmid: 9504433
[36]	Li S, Han XM, Guo YM. Progress of researches on the development of non-benzimidazoles for the treatment of echinococcosis[J]. Chin J Schisto Control, 2021, 33(2):213-217. (in Chinese)
	( 李松, 韩秀敏, 郭亚民. 非苯并咪唑类药物用于棘球蚴病治疗研究进展[J]. 中国血吸虫病防治杂志, 2021, 33(2):213-217.)
[37]	Li YQ, Ren YS, Wang LJ, et al. Preparation. Preparation and antibacterial activity of the Moslae Herba volatile oil nanoemulsion spray[J]. Chin J Chin Mater Med, 2021. https://doi.org/10.19540/j.cnki.cjcmm.20210408.302. (in Chinese)
	( 李艳秋, 任永申, 王丽君, 等. 香薷挥发油纳米乳喷雾的制备及其抗菌活性的研究[J]. 中国中药杂志, 2021. https://doi.org/10.19540/j.cnki.cjcmm.20210408.302. )
[38]	Zhu JH, Cao DP, Qie YRZ, et al. Effect of Elsholtzia eriostachya in combination with albendazole in treatment of secondary Echinococcus multilocularis metacestode infection in rats[J]. Chin J Parasitol Parasit Dis, 2020, 38(6):688-694. (in Chinese)
	( 朱吉海, 曹得萍, 切羊让中, 等. 藏药黄花香薷联合阿苯达唑治疗大鼠继发性多房棘球蚴感染的疗效研究[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(6):688-694.)
[39]	Chen MY, Gu ZL. Research status of lycorine pharmacological action[J]. Chin J Clin Pharmacol, 2021, 37(4):469-472. (in Chinese)
	( 陈茂杨, 顾志良. 石蒜碱药理作用的研究现状[J]. 中国临床药理学杂志, 2021, 37(4):469-472.)
[40]	Yang LZ, Peng XY, Zhang HW, et al. Study on the action of lycorine and lycorine combined with albendazole against Echinococcus granulosus protoscoleces in vitro[J]. J Pathog Biol, 2020, 15(3):265-268, 273. (in Chinese)
	( 杨凌志, 彭心宇, 张宏伟, 等. 石蒜碱及其与阿苯达唑联合体外抗细粒棘球蚴原头节的作用研究[J]. 中国病原生物学杂志, 2020, 15(3):265-268, 273.)
[41]	Yin QN, Chen XL, Xiao HT. Research progress of the pharmacological effect of harmine[J]. Chin J Clin Pharmacol, 2019, 35(6):594-596, 600. (in Chinese)
	( 尹琪楠, 陈晓玲, 肖洪涛. 去氢骆驼蓬碱药理作用研究现状[J]. 中国临床药理学杂志, 2019, 35(6):594-596, 600.)
[42]	Li LH, Zhao J, Ma YF, et al. Experimental study of harmine and albendazole on echinococcosis infection in mice[J]. J Pathog Biol, 2016, 11(9):815-820. (in Chinese)
	( 李丽华, 赵军, 马运芳, 等. 去氢骆驼蓬碱和阿苯达唑联合治疗小鼠腹腔细粒棘球蚴病的实验研究[J]. 中国病原生物学杂志, 2016, 11(9):815-820.)
[43]	Li J, Chen HY, Zhang WH, et al. Research progress on pharmacological effects of phenolic compounds in pomegranate peel[J]. Cereals Oils, 2020, 33(12):4-6. (in Chinese)
	( 李佳, 陈皓玉, 张文慧, 等. 石榴皮中酚类化合物药理作用研究进展[J]. 粮食与油脂, 2020, 33(12):4-6.)
[44]	Labsi M, Soufli I, Khelifi L, et al. A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: An alternative approach[J]. Acta Trop, 2019, 197:105050. doi: 10.1016/j.actatropica.2019.105050
[45]	Wang SY, Sun ZL, Liu T, et al. Flavonoids from Sophora moorcroftiana and their synergistic antibacterial effects on MRSA[J]. Phytother Res, 2014, 28(7):1071-1076. doi: 10.1002/ptr.5098
[46]	Pan RC, Zhang FB, Cheng SL, et al. A study on treatment of secondary hepatic hydatid disease in mice with alkaloids extracted from Sophora moorcroftiana seeds[J]. J Pathog Biol, 2018, 13(3):254-258. (in Chinese)
	( 潘汝翀, 张发斌, 程时磊, 等. 砂生槐生物碱治疗继发性小鼠肝包虫病的实验研究[J]. 中国病原生物学杂志, 2018, 13(3):254-258.)
[47]	Zhang F, Hu C, Cheng S, et al. The investigation of the effect and mechanism of Sophora moorcroftiana alkaloids in combination with albendazole on echinococcosis in an experimental rats model[J]. Evid Based Complement Alternat Med, 2018, 2018:3523126.