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Research Progress on the Role of Small Non-coding RNA in Schistosoma Infection

YANG Jie1, QIN Zhi-qiang2 *, XU Jing2, QIAN Ying-jun2, ZHOU Dong-ming3   

  1. 1 Yiyang Medical College, Yiyang 413002, China; 2 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; WHO Collaborating Centre for Tropical Diseases, Shanghai 200025, China; 3 Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
  • Online:2016-06-30 Published:2016-10-28

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Abstract: Small non-coding RNA controls the expression of target genes and is related with mRNA degradation, chromatin modification and genome stability. Recent studies showed that small non-coding RNA is not only associated with the incidence of schistosomiasis, but also acts as a potential biomarker. In this article, we will review the applications of small non-coding RNA in schistosomiasis diagnosis and its potential role in schistosome development and pathogenesis, in the aim to provide hints for developing detection methods and vaccines for schistosomiasis and for drug development.

Key words: Small non-coding RNA, Schistosomiasis, Biomarker