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Research Advances on Toxoplasma gondii Proteomics

QIU Jingfan, GE Ke, WANG Yong*   

  1. Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
  • Online:2015-06-30 Published:2015-09-08

Abstract:

【Abstract】 The proteomic techniques have been widely used in Toxoplasma gondii research since the past decade, providing proteomic data that facilitate understanding of T. gondii activities. Currently, the global proteomic studies of T. gondii are mainly confined to the tachyzoite and the oocyst stages. The subproteomic research involves some important antigens, such as the soluble tachyzoite antigen, glycoproteins, and immunoproteins, etc. The differential proteomics of T. gondii is mainly focused on identifying differentially-expressed proteins in different T. gondii strains. This review summarizes the current status of proteomic research on T. gondii, with specific focuses on global proteomic, subproteomic, and differential proteomic findings. In addition, this review gives an overview on web-based resources that provide proteomic data and support for studies on T. gondii, and finally discusses future prospects of T. gondii proteomics applications.

Key words: Toxoplasma gondii, Proteomics, Excretory-secretory antigen, Soluble tachyzoite antigen