Research Progress on the Action of Praziquantel on Voltage-gated Ca2+ Channel in Schistosomes

›› 2008, Vol. 26 ›› Issue (1): 13-62.

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Research Progress on the Action of Praziquantel on Voltage-gated Ca²⁺ Channel in Schistosomes

ZHANG Ling, ZHOU Xiao-nong*

National Institute of Parasitic Diseases，Chinese Center for Disease Control and Prevention；Laboratory of Parasite and Vector Biology，MOH，China; WHO Collaborating Centre of Malaria，Schistosomiasis and Filariasis，Shanghai 200025，China

Received:1900-01-01 Revised:1900-01-01 Online:2008-02-28 Published:2008-02-28
Contact: ZHOU Xiao-nong

Abstract

Abstract: Pharmacological actions of praziquantel against schistosome adult worms are thought to be directly linked to the disruption of Ca²⁺ homeostasis. The voltage-gated Ca²⁺ channel is an important factor in regulating the intracellular Ca²⁺ level. Studies have revealed that Ca²⁺ channel subunits may be the target for the action of praziquantel. This review summarizes the progress on the structure and function of the Ca²⁺ channel of Schistosoma spp and other Platyhelminths as well as the role of Ca2+ channel in action of praziquantel.

Key words: Praziquantel, Ca²⁺ channel, Voltage-gated, Schistosome

ZHANGLing;ZHOUXiao-nong*. Research Progress on the Action of Praziquantel on Voltage-gated Ca²⁺ Channel in Schistosomes[J]. , 2008, 26(1): 13-62.

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Research Progress on the Action of Praziquantel on Voltage-gated Ca²⁺ Channel in Schistosomes

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