Abstract: AIM:To assess clinical value of detecting specific antibodies in sera by using
ELISA in diagnsis of neurocysticercosis.METHODS:Specific antibodies to cysticerci were examined
with ELISA in2 82 suspected neurocyticercosis cases having been experienced initial CT scan-
ning. All cases were further subjected to either of the following procedures:contrast en- hanced
CT,MR,CSF assay,surgery,anticysticercous therapy.For confirmed cysticercosis cases,albendazole2
0 mg/ (kg·d)× 1 0 was administered.RESULTS:Eighty-nine (31. 6% )persons were defined definitely as neurocysticercosis cases. The specificity and sensitivity of serum /ELISA for diagnosis of neurocysticercosis were 89. 1% and 69. 7% , respectively; and of CSF/ELISA , 8/8 and 8/20 (cases). The pathological aspects of the disease including location and number and duration of cysticerci would affect positive rate and intensity of serum/ELISA. The cytological changes in CSF revealed a significant correlation with CSF/ELISA results (P < 0. 01). CONCLUSION: ELISA used in detecting specific antibodies in patients’ sera is a promising supplementary tool in diagnosis of neurocysticercosis. It can be used to screen the disease in endemic area. Combined use of CT/MR and serum/EL ISA may make the diagnosis more accurate and reliable

Key words: Neurocysticercosis, ELISA, antibody, CT, experimental treatment