CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2020, Vol. 38 ›› Issue (2): 250-254.doi: 10.12140/j.issn.1000-7423.2020.02.019

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Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis

Xiao LI1, Jiang-chang WANG2, Lei GUAN2, Qi GU2, Ji-ze DONG2, Chen-yun WU2, Min YAN1, Zhao-jun WANG2,3,*()   

  1. 1 Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, China
    2 Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    3 School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2019-07-29 Online:2020-04-30 Published:2020-05-11
  • Contact: Zhao-jun WANG E-mail:zjwang@sjtu.edu.cn
  • Supported by:
    Supported by the Natural Science Foundation of Shanghai(19ZR1428500);the National Natural Science Foundation of China(81971486)

Abstract:

Clonorchis sinensis is a food-borne parasite that can cause hepatobiliary lesions and even cholangiocarcinoma. This review summarizes recent progress in the pathogenesis of cholangiocarcinoma caused by C. sinensis, from perspectives of toxicity of worms, abnormal immune responses of hosts and co-infection with other pathogens.

Key words: Clonorchis sinensis, Cholangiocarcinoma, Excretory/secretory products, Immune factors

CLC Number: