阿苯达唑联合药物治疗棘球蚴病的研究进展

doi:10.12140/j.issn.1000-7423.2022.05.013

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (5): 647-655.doi: 10.12140/j.issn.1000-7423.2022.05.013

阿苯达唑联合药物治疗棘球蚴病的研究进展

秦敏¹(), 王立英¹^,²^,³^,^*()

1.中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,科技部国家级热带病国际研究中心,上海 200025
2.西藏自治区疾病预防控制中心,国家卫生健康委包虫病防治研究重点实验室,拉萨 850000
3.蒙彼利埃大学,法国 34395

收稿日期:2022-01-19 修回日期:2022-01-25 出版日期:2022-10-30 发布日期:2022-08-12
通讯作者: 王立英
作者简介:秦敏(1996-),女,硕士研究生,从事传染病流行病学研究。E-mail： qmkx0106@163.com
基金资助:
国家自然科学基金(81703281);国家卫生健康委包虫病防治研究重点实验室开放课题(2021WZK1006)

Research progress on combined use of drugs with albendazole in the treatment of echinococcosis

QIN Min¹(), WANG Li-ying¹^,²^,³^,^*()

1. National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention (Chinese Centre for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Centre for International Research on Tropical Diseases, Shanghai 200025, China
2. Tibet Center for Disease Control and Prevention; NHC Key Laboratory of Echinococcosis Prevention and Control, Lhasa 850000, China
3. Doctorate School of Chemical and Biological Sciences for Health (CBS2); University of Montpellier,Montpellier 34395, France

Received:2022-01-19 Revised:2022-01-25 Online:2022-10-30 Published:2022-08-12
Contact: WANG Li-ying
Supported by:
National Natural Science Foundation of China(81703281);NHC Key Laboratory of Echinococcosis Prevention and Control, China(2021WZK1006)

摘要/Abstract

摘要：

棘球蚴病是严重危害农牧民身体健康和生命安全的一种寄生虫病,临床治疗药物以阿苯达唑为主。但阿苯达唑的生物利用度低,需要患者加大药量且长期服用,这会产生一定的不良反应,并可能出现耐药性。为了提高阿苯达唑的疗效,减少药物对机体的损害,关注阿苯达唑联合用药的研究越来越多。本文重点对其他药物联合阿苯达唑治疗棘球蚴病的研究进展进行综述,以期为今后棘球蚴病患者药物治疗的深入研究和应用提供参考。

关键词: 棘球蚴病, 阿苯达唑, 药物治疗, 联合治疗

Abstract:

Echinococcosis is a parasitic disease that seriously affects the health and life safety of farmers and herdsmen. Albendazole is the primary clinical drug. However, the bioavailability of albendazole is low, requiring patients to increase the dosage and take medicine for a long time, producing certain adverse reactions and drug resistance. In order to improve the efficacy of albendazole and reduce the damage of drugs to the body, more and more studies pay attention to the combination of albendazole. This paper focuses on the advances progress of other drugs combined with albendazole in the treatment of echinococcosis to provide a reference for the further research and application of drug therapy in patients with echinococcosis.

Key words: Echinococcosis, Albendazole, Medication, Combination therapy

中图分类号:

R532.32

秦敏, 王立英. 阿苯达唑联合药物治疗棘球蚴病的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(5): 647-655.

QIN Min, WANG Li-ying. Research progress on combined use of drugs with albendazole in the treatment of echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(5): 647-655.

图/表 2

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[76]	Huang Y,, Yu WJ,, Shang JY, et al. Efficacy of alternative and combined use of albendazole plus praziquantel in the treatment of echinococcosis for Tibetan herdsmen[J]. Chin J Parasitol Parasit Dis, 2021, 39(2): 171-177. (in Chinese)
[76]	( 黄燕,, 喻文杰,, 尚婧晔, 等. 阿苯达唑和吡喹酮交替联合用药治疗藏族牧民棘球蚴病的效果观察[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(2): 171-177.)
[77]	Wang LY,, Qin M,, Liu ZH, et al. Prevalence and spatial distribution characteristics of human echinococcosis in China[J]. PLoS Negl Trop Dis, 2021, 15(12): e0009996.

药物	虫种	剂量	给药方式	作用时间	实验结果^a	参考文献
大蒜甲醇提取物	细粒棘球绦虫	10 ml/L大蒜甲醇提取物 + 50 mg/kg阿苯达唑	腹腔注射	30 d	有效	[20]
细胞因子（IL-12和IFN-γ）	细粒棘球绦虫	10 μg/kg IL-12 + 25 μg/kg IFN-γ + 50 mg/kg阿苯达唑	腹腔注射	90 d	有效	[27]
IFN-α	细粒棘球绦虫	10 000 IU/50μl IFN-α + 5 mg/kg阿苯达唑	肌肉注射+灌胃	60 d	有效	[30]
青蒿琥酯	细粒棘球绦虫	100 mg/(kg·d)青蒿琥酯 + 75 mg/(kg·d)阿苯达唑	灌胃	90 d	有效	[37]
青蒿琥酯	细粒棘球绦虫	200 mg/(kg·bw)青蒿琥酯 + 50 mg/(kg·bw)阿苯达唑	灌胃	6周	无效	[38]
去氢骆驼蓬碱	细粒棘球绦虫	10 mg/kg去氢骆驼蓬碱 + 50 mg/kg阿苯达唑	腹腔注射	14 d	有效	[40]
砂生槐	细粒棘球绦虫	8 mg/(kg·d)砂生槐 + 10 mg/(kg·d)阿苯达唑	灌胃	90 d	无效	[73]
阿托伐酮	多房棘球绦虫	133 mg/100g阿托伐酮 + 125 mg/100g阿苯达唑	口服	8周	有效	[50]
香芹酚	多房棘球绦虫	40 mg/kg香芹酚 + 25 mg/kg阿苯达唑	灌胃	30 d	有效	[53]
姜黄素	多房棘球绦虫	1.25 mg/d姜黄素 + 1.25 mg/d阿苯达唑	灌胃	60 d	无效	[60]
异甘草酸镁	多房棘球绦虫	45 mg/(kg·d)异甘草酸镁 + 50 mg/(kg·d)阿苯达唑	腹腔注射	60 d	有效	[63]
黄花香薷	多房棘球绦虫	25 mg/(kg·d)黄花香薷 + 25 mg/(kg·d)阿苯达唑	灌胃	56 d	有效	[66]
砂生槐	多房棘球绦虫	砂生槐子生物缓释粘附片1片 + 50 mg/(kg·d)阿苯达唑	灌胃	30 d	有效	[74]

药物	虫种	浓度	作用时间	死亡率/%	参考文献
亚砷酸钠	细粒棘球绦虫	20 μmol/l亚砷酸钠 + 80 μmol/l阿苯达唑	4 d	100	[24]
铜纳米颗粒	细粒棘球绦虫	750 mg/ml铜纳米颗粒 + 200 mg/ml阿苯达唑	10 min	100	[34]
百里酚	多房棘球绦虫	10 μg/ml百里酚 + 10 μg/ml阿苯达唑	25 d	50	[67]
石蒜碱	细粒棘球绦虫	100 μmol/l石蒜碱 + 50 μmol/l阿苯达唑	9 d	49.8	[44]
水飞蓟乙醇提取物	多房棘球绦虫	500 μg/ml水飞蓟乙醇提取物 + 500 μg/ml阿苯达唑	60 min	100	[48]
香芹酚	多房棘球绦虫	10 μg/ml香芹酚 + 1 μg/ml阿苯达唑	5 d	54.23	[46]

阿苯达唑联合药物治疗棘球蚴病的研究进展

Research progress on combined use of drugs with albendazole in the treatment of echinococcosis

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