棘球蚴感染致肝纤维化的研究进展

doi:10.12140/j.issn.1000-7423.2022.05.014

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (5): 656-660.doi: 10.12140/j.issn.1000-7423.2022.05.014

棘球蚴感染致肝纤维化的研究进展

蒋小凤¹(), 沈玉娟¹^,²^,^*()

1.1中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）,国家卫生健康委寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海 200025
2.上海交通大学医学院-国家热带病研究中心全球健康学院,上海 200025

收稿日期:2022-03-22 修回日期:2022-05-09 出版日期:2022-10-30 发布日期:2022-10-14
通讯作者: 沈玉娟
作者简介:蒋小凤（1997-）,女,硕士研究生,从事寄生虫感染免疫研究。E-mail： 463434450@qq.com
基金资助:
国家自然科学基金(82072307);国家自然科学基金(81772224)

Research progress on liver fibrosis caused by Echinococcus infection

JIANG Xiao-feng¹(), SHEN Yu-juan¹^,²^,^*()

1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases; Shanghai 200025, China
2. School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2022-03-22 Revised:2022-05-09 Online:2022-10-30 Published:2022-10-14
Contact: SHEN Yu-juan
Supported by:
National Natural Science Foundation of China(82072307);National Natural Science Foundation of China(81772224)

摘要/Abstract

摘要：

棘球蚴感染会对人肝细胞造成损伤。肝纤维化是肝脏发生损伤后,结缔组织过度增生的过程。在肝脏自我修复的动态过程中肝星状细胞激活、细胞外基质生成增加而消耗减少,引起肝纤维化。本文就棘球蚴感染所致肝纤维化中肝星状细胞、多种细胞因子和微小核糖核酸的调控机制作一综述。

关键词: 棘球蚴, 肝纤维化, 细胞因子, 微小RNA

Abstract:

Echinococcus infection may cause damage to hepatocytes. Hepatic fibrosis is a process of excessive proliferation of connective tissue after liver injury. In the dynamic process of liver self-healing, the activation of hepatic stellate cells, the increased extracellular matrix production and the decreased extracellular matrix consumption result in fibrosis. This review summarizes the regulatory mechanisms of hepatic stellate cells, cytokines and microRNA involved in hepatic fibrosis caused by Echinococcus infection.

Key words: Echinococcus, Hepatic fibrosis, Cytokines, MicroRNA

中图分类号:

R532.32

蒋小凤, 沈玉娟. 棘球蚴感染致肝纤维化的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(5): 656-660.

JIANG Xiao-feng, SHEN Yu-juan. Research progress on liver fibrosis caused by Echinococcus infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(5): 656-660.

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棘球蚴感染致肝纤维化的研究进展

Research progress on liver fibrosis caused by Echinococcus infection

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