刚地弓形虫诱导宿主精神行为障碍的研究进展

doi:10.12140/j.issn.1000-7423.2022.05.012

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (5): 642-646.doi: 10.12140/j.issn.1000-7423.2022.05.012

刚地弓形虫诱导宿主精神行为障碍的研究进展

代莉莎(), 张丽新, 尹昆()

山东省寄生虫病防治研究所,山东第一医科大学（山东省医学科学院）,济宁 272033

收稿日期:2022-01-19 修回日期:2022-01-25 出版日期:2022-10-30 发布日期:2022-08-15
通讯作者: 尹昆
作者简介:代莉莎（1995-）,女,硕士研究生,从事弓形虫病研究。E-mail： 675172057@qq.com
基金资助:
山东省泰山学者工程项目(tsqn202103186);山东省医药卫生科技发展计划项目(202101050270);山东第一医科大学学术提升计划项目(2019QL005);山东省医学科学院医药卫生科技创新工程

Research advances in Toxoplasma gondii induced host mental-behavioural disorders

DAI Li-sha(), ZHANG Li-xin, YIN Kun()

Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining 272033, China

Received:2022-01-19 Revised:2022-01-25 Online:2022-10-30 Published:2022-08-15
Contact: YIN Kun
Supported by:
Taishan Scholars Project of Shandong Province(tsqn202103186);Shandong Medical and Health Science and Technology Development Project(202101050270);Academic Promotion Program of Shandong First Medical University(2019QL005);Shandong Academy of Medical Sciences, Medical and Health Science and Technology Innovation Project

摘要/Abstract

摘要：

刚地弓形虫可引起人兽共患寄生虫病,弓形虫组织包囊引起的慢性感染可导致宿主神经系统功能异常,诱发宿主行为改变或精神障碍,如导致寄生动物宿主降低对捕食者的恐惧等,人类宿主的多种精神障碍也与慢性感染显著相关。目前已知介导该过程可能的机制,包括脑包囊感染、中枢神经递质失衡,以及表观遗传调控“行为操纵”等,但确切机制尚不明确。本文就刚地弓形虫感染导致宿主精神行为异常的相关研究,以及目前研究较为深入的发生机制研究进展进行综述。

关键词: 刚地弓形虫, 脑包囊, 神经递质, 行为操纵, 表观遗传

Abstract:

Toxoplasma gondii can cause zoonotic parasitic diseases in humans and animals. Chronic toxoplasmosis induced by toxoplasma cysts could cause nervous system dysfunction, behavioural changes or mental disorders in the hosts, including reducing the natural fear of predators in the rodent host. Multiple psychiatric disorders in human hosts were also significantly associated with T. gondii chronic infection. The possible mechanisms that regulate this process include cerebral cyst infection, central neurotransmitter disorders, and epigenetic regulation of“behavioural manipulation”, but the precise mechanism remains unclear. In this review, we have summarized relevant studies of the host abnormal mental behaviour induced by T. gondii, and summarized the well-established mechanism(s) for this process.

Key words: Toxoplasma gondii, Brain cyst, Neurotransmitter, Behavioral manipulation, Epigenetics

中图分类号:

R531.8

代莉莎, 张丽新, 尹昆. 刚地弓形虫诱导宿主精神行为障碍的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(5): 642-646.

DAI Li-sha, ZHANG Li-xin, YIN Kun. Research advances in Toxoplasma gondii induced host mental-behavioural disorders[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(5): 642-646.

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刚地弓形虫诱导宿主精神行为障碍的研究进展

Research advances in Toxoplasma gondii induced host mental-behavioural disorders

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