弓形虫外泌体研究进展

doi:10.12140/j.issn.1000-7423.2020.05.020

中国寄生虫学与寄生虫病杂志 ›› 2020, Vol. 38 ›› Issue (5): 653-657.doi: 10.12140/j.issn.1000-7423.2020.05.020

弓形虫外泌体研究进展

李朋举¹(), 左素琼¹, 段玉娟¹, 李浩然¹^,², 张振超¹^,², 李祥瑞¹^,²^,³, 王帅¹^,²^,^*()

1 新乡医学院基础医学院,新乡 453003
2 新乡医学院新乡市病原生物学重点实验室,新乡 453003
3 南京农业大学动物医学院,南京 210095

收稿日期:2020-02-22 出版日期:2020-10-30 发布日期:2020-11-12
通讯作者: 王帅
作者简介:李朋举（1997-）,男,本科生,从事弓形虫研究。E-mail:a1251632651@qq.com
基金资助:
国家自然科学基金项目(81702025);河南省科技攻关计划项目(182102310220);新乡医学院博士科研启动基金(XYBSKYZZ201504)

Advances in research on exosomes of Toxoplasma spp.

LI Peng-ju¹(), ZUO Su-qiong¹, DUAN Yu-juan¹, LI Hao-ran¹^,², ZHANG Zhen-chao¹^,², LI Xiang-rui¹^,²^,³, WANG Shuai¹^,²^,^*()

1 School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China
2 Xinxiang Key Laboratory of Pathogenic Biology, Xinxiang Medical University, Xinxiang 453003, China
3 College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Received:2020-02-22 Online:2020-10-30 Published:2020-11-12
Contact: WANG Shuai
Supported by:
National Natural Science Foundation of China(81702025);Science and Technology Project of Henan Province(182102310220);Doctoral Research Fund of Xinxiang Medical University(XYBSKYZZ201504)

摘要/Abstract

摘要：

外泌体是一种由多种细胞分泌的细胞外囊泡,包含蛋白质、脂质、核酸等多种活性成分。研究表明,多数寄生虫也能分泌外泌体,其在介导虫体-宿主细胞间信息交流、调节宿主免疫反应、传递致病因子、药物抗性基因和分化因子等方面扮演着重要的角色。此外,基于外泌体进行的治疗和疫苗研制方兴未艾。本文主要对弓形虫外泌体的生物学特征和功能进行总结,并对其应用前景进行阐述。

关键词: 弓形虫, 外泌体, 免疫调节, 应用

Abstract:

Exosomes are a type of extracellular vesicles secreted by a variety of cells, and contain many active components such as proteins, lipids, and nucleic acids. Studies have shown that a majority of parasites can secrete exosomes, which play important roles in mediating communications between parasites and host cells, regulating host immune responses, as well as transmitting pathogenic factors, drug resistance-associated genes and differentiation factors. In addition, exosome-based therapies and vaccine development are still under the way. In this paper, we summarize the biological characteristics and functions of exosomes secreted by Toxoplasma spp., and discuss their application potentials.

Key words: Toxoplasma, Exosome, Immunomodulation, Application

中图分类号:

R382.5

李朋举, 左素琼, 段玉娟, 李浩然, 张振超, 李祥瑞, 王帅. 弓形虫外泌体研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(5): 653-657.

LI Peng-ju, ZUO Su-qiong, DUAN Yu-juan, LI Hao-ran, ZHANG Zhen-chao, LI Xiang-rui, WANG Shuai. Advances in research on exosomes of Toxoplasma spp.[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(5): 653-657.

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弓形虫外泌体研究进展

Advances in research on exosomes of Toxoplasma spp.

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