广州管圆线虫主要中间宿主螺类防控药物前沿进展

doi:10.12140/j.issn.1000-7423.2026.04.019

中国寄生虫学与寄生虫病杂志 ›› 2026, Vol. 44 ›› Issue (4): 587-594.doi: 10.12140/j.issn.1000-7423.2026.04.019

广州管圆线虫主要中间宿主螺类防控药物前沿进展

王味思¹()(), 陈盈¹, 孙杨², 黄水金², 骆焱平³, 柯少勇⁴, 段李平¹^,^*()

¹ 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），传染病溯源预警与智能决策全国重点实验室，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，科技部国家级热带病国际联合研究中心，上海 200025
² 江西省农业科学院植物保护研究所，江西南昌 330200
³ 海南大学热带农林学院，海南海口 570228
⁴ 湖北省农业科学院/湖北省生物农药工程研究中心，湖北武汉 430064

收稿日期:2026-03-02 修回日期:2026-06-01 出版日期:2026-08-30 发布日期:2026-08-26
通讯作者: * 段李平，男，博士，研究员，从事寄生虫和媒介防治研究。E-mail：duanlp@nipd.chinacdc.cn
作者简介:王味思（ORCID：0000-0002-7112-0160），女，博士，副研究员，从事抗热带病新药研发。E-mail：wangws@nipd.chinacdc.cn
作者贡献
王味思负责文献收集和论文撰写，陈盈和孙杨负责文献收集，黄水金、骆焱平、柯少勇和段李平负责论文审校和修改。
基金资助:
江西省重点研发计划(20261BCF320032);国家自然科学基金(82072309)

Advances in molluscicides against major snail intermediate hosts of Angiostrongylus cantonensis

WANG Weisi¹()(), CHEN Ying¹, SUN Yang², HUANG Shuijin², LUO Yanping³, KE Shaoyong⁴, DUAN Liping¹^,^*()

¹ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
² Institute of Plant Protection, Jiangxi Academy of Agricultural Sciences, Nanchang 330200, Jiangxi, China
³ School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, Hainan, China
⁴ Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, Hubei, China

Received:2026-03-02 Revised:2026-06-01 Online:2026-08-30 Published:2026-08-26
Contact: * E-mail: duanlp@nipd.chinacdc.cn
Supported by:
Key R&D Program of Jiangxi Province, China(20261BCF320032);Natural Science Foundation of China(82072309)

摘要/Abstract

摘要：

广州管圆线虫病是一种新发的人兽共患病，福寿螺和褐云玛瑙螺是其主要中间宿主。这两种螺类种群的规模扩散显著加剧了疾病传播风险。使用杀螺剂控制中间宿主种群是阻断该病传播的有效策略之一。本文系统综述了针对上述两种螺类的防控药物研究进展，重点梳理了以化学杀螺剂为主导、植物源与微生物源杀螺剂为补充、RNA杀螺剂为前沿探索、引诱剂用于行为调控的研究格局，以期为新型杀螺剂的研发与广州管圆线虫病的综合防控提供有益参考。

关键词: 广州管圆线虫, 福寿螺, 褐云玛瑙螺, 杀螺剂, 引诱剂

Abstract:

Angiostrongyliasis is an emerging zoonosis. Its primary intermediate hosts, the apple snails (Pomacea) and giant African land snails (Achatina fulica), have significantly exacerbated the risk of disease transmission through their population expansion. Applying molluscicides to control these intermediate host populations is an effective strategy for interrupting disease transmission. This review systematically summarizes the research progress on molluscicides for controlling these two snail species. It provides a focused overview of the current research landscape, which features chemical molluscicides as the dominant approach, complemented by plant-derived and microbial molluscicides, alongside RNA-based molluscicides in the frontier exploratory stage and attractants employed for behavioral regulation. This review aims to serve as a valuable reference for the development of novel molluscicides and the integrated control of angiostrongyliasis.

Key words: Angiostrongylus cantonensis, Pomacea, Achatina fulica, Molluscicide, Attractant

中图分类号:

R533.1

王味思, 陈盈, 孙杨, 黄水金, 骆焱平, 柯少勇, 段李平. 广州管圆线虫主要中间宿主螺类防控药物前沿进展[J]. 中国寄生虫学与寄生虫病杂志, 2026, 44(4): 587-594.

WANG Weisi, CHEN Ying, SUN Yang, HUANG Shuijin, LUO Yanping, KE Shaoyong, DUAN Liping. Advances in molluscicides against major snail intermediate hosts of Angiostrongylus cantonensis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2026, 44(4): 587-594.

图/表 3

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杀螺剂	杀螺活性^a	鱼毒性	主要作用靶点	参考文献
吡螺脲	48 h LC₅₀ = 0.39 mg/L	斑马鱼：96 h LC₅₀ = 11.96 mg/L	6-磷酸果糖激酶	[5,7]
氟吡啶苯基脲类	LC₅₀ = 1.0 mg/L	鲤鱼和草鱼：10 mg/L，72 h死亡率0	6-磷酸果糖激酶	[13]
二苯基脲类	5 mg/L，螺死亡率100%	鲤鱼苗：20 mg/L，72 h死亡率16.7%	6-磷酸果糖激酶	[14]
甲苯达唑	LC₅₀ = 0.307 mg/L	斑马鱼：96 h LC₅₀ = 5.398 mg/L	β-微管蛋白	[15]
丁醚脲	LC₅₀ = 0.13 mg/L	斑马鱼：96 h LC₅₀ = 0.19 mg/L	ATP合成酶	[16-17]
溴虫腈	LC₅₀ = 0.04 mg/L	斑马鱼：96 h LC₅₀ = 0.015 mg/L	线粒体氧化磷酸化解偶联	[16,18]
巴氯芬	LC₅₀ = 16.2 mg/L	/	小根蛋白	[19]
硫代烟酰胺腺嘌呤二核苷酸	LC₅₀ = 57.7 mg/L	/	神经Wiskott-Aldrich综合征蛋白异构体X1	[20]

植物种属	杀螺活性成分	靶标螺类	杀螺活性^a	主要作用靶点	参考文献
苦葛	苦葛皂苷A	小管福寿螺	LC₅₀ = 3.89 mg/L	Advillin	[22,24]
槟榔	槟榔碱	小管福寿螺	LC₅₀ = 1.05 mg/L	小根蛋白	[25]
雷公藤	雷公藤甲素	小管福寿螺	LC₅₀ = 0.09 mg/L	β-微管蛋白	[26]
大叶紫珠	(E)-β-石竹烯	小管福寿螺	24 h LC₅₀ = 16.67 mg/L	尚待研究	[27]
大叶紫珠	β-蒎烯	小管福寿螺	24 h LC₅₀ = 6.91 mg/L	尚待研究	[27]
豚草	Psilostachyin	小管福寿螺	24 h LC₅₀ = 15.9 mg/L	尚待研究	[28]
豚草	Psilostachyin B	小管福寿螺	24 h LC₅₀ = 27.0 mg/L	尚待研究	[28]
木荷	Maetenoside B	小管福寿螺	20 mg/L，螺死亡率100%	尚待研究	[29]
木荷	油茶皂苷Ⅲ	小管福寿螺	20 mg/L，螺死亡率100%	尚待研究	[29]
补骨脂	补骨脂甲素	小管福寿螺	LC₅₀ = 30.91 mg/L	尚待研究	[30]
唇形科植物	百里酚	褐云玛瑙螺	成螺：24 h LC₅₀ = 3 000 mg/L	尚待研究	[34]
唇形科植物	百里酚	褐云玛瑙螺	幼螺：24 h LC₅₀ = 50 mg/L	尚待研究	[34]

防控策略	杀螺效率	起效速度	非靶标生物安全性	环境风险	生产成本	适用场景
化学杀螺剂	★★★★☆ 高（LC₅₀多在0.01^-1 mg/L级）	★★★★☆ 快（几小时至数天）	★★☆☆☆ 传统品种高风险，新型产品显著降低	★★★☆☆ 较高，传统品种残留高，新型产品逐步改善	★★★☆☆ 中等，规模化生产成熟	暴发期应急响应种群压制、大面积农田/水域
植物源杀螺剂	★★★☆☆ 中等至高	★★★☆☆ 中等（数天）	★★★☆☆ 总体中等，部分对鱼类有毒	★★☆☆☆ 较低，易降解，残留低	★★★☆☆ 总体中等，植物提取物原料易得、成本可控，活性单体提取/合成成本较高	生态敏感区、日常防控、有机农业
微生物源杀螺剂	★★★☆☆ 中等（对幼螺/卵效果好）	★☆☆☆☆ 慢（数天至数周）	★★★★☆ 特异性较强，引入风险需评估	★☆☆☆☆ 低，自然归趋	★★★★☆ 较高（生产、储存、施用要求高）	长期治理、配合其他措施
RNA杀螺剂	★★★★☆ 潜力高	★★★☆☆ 中等（需基因沉默时间）	★★★★★ 极低，高序列特异性对非靶标影响较小	★☆☆☆☆ 低，dsRNA自然降解，纳米载体包裹后有可能延长半衰期	★★★★★ 高（规模化合成待突破）	精准防控、局部施药、抗药性治理
引诱剂	★☆☆☆☆ 不直接杀灭，依赖配套措施	★★★★★ 极快（几分钟至几小时）	★★★☆☆ 食物引诱剂特异性较低，性引诱剂专一	★☆☆☆☆ 低，生物相容性高	★★☆☆☆ 总体较低，食物引诱剂来源广泛，性引诱剂结构复杂但用量较低	监测、诱杀、交配干扰、集中处理

广州管圆线虫主要中间宿主螺类防控药物前沿进展

Advances in molluscicides against major snail intermediate hosts of Angiostrongylus cantonensis

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