白蛉肠道微生态与利什曼原虫感染相互作用研究进展

doi:10.12140/j.issn.1000-7423.2025.05.017

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (5): 711-717.doi: 10.12140/j.issn.1000-7423.2025.05.017

白蛉肠道微生态与利什曼原虫感染相互作用研究进展

何雅琦¹()(), 崔蕾¹, 方圆¹^,², 周正斌¹, 张仪¹^,²^,^*()()

1 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），传染病溯源预警与智能决策全国重点实验室，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，科技部国家级热带病国际联合研究中心，上海 200025
2 上海交通大学医学院-国家热带病研究中心全球健康学院，上海 200025

收稿日期:2025-05-09 修回日期:2025-07-24 出版日期:2025-10-30 发布日期:2025-10-23
通讯作者: *张仪（ORCID：0000-0002-3169-1823），女，硕士，研究员，从事寄生虫与媒介的研究。E-mail：zhangyi@nipd.chinacdc.cn
作者简介:何雅琦（ORCID：0009-0005-9274-502X），女，硕士研究生，从事医学媒介生物防制的研究。E-mail：Hheyq1005@163.com
基金资助:
国家重点研发计划(2023YFA1801000);国家重点研发计划(2023YFA1801001)

Progress of researches on interactions between sandfly gut microecology and Leishmania infection

HE Yaqi¹()(), CUI Lei¹, FANG Yuan¹^,², ZHOU Zhengbin¹, ZHANG Yi¹^,²^,^*()()

1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; NHC Key Laboratory on Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
2 School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2025-05-09 Revised:2025-07-24 Online:2025-10-30 Published:2025-10-23
Contact: *E-mail: zhangyi@nipd.chinacdc.cn
Supported by:
National Key Research and Development Program of China(2023YFA1801000);National Key Research and Development Program of China(2023YFA1801001)

摘要/Abstract

摘要：

白蛉作为多种病原体的传播媒介具有重要的流行病学意义，尤其以传播利什曼原虫而广受关注。利什曼原虫的生长发育受到白蛉肠道内多种微生物的影响，同时也会导致白蛉肠道内某些基因差异表达。本文综述了白蛉肠道微生物的组成及其与利什曼原虫的相互作用，以及利什曼原虫导致白蛉肠道功能特征的改变。白蛉、利什曼原虫、微生物群、相关基因的表达之间存在复杂的网络关系，研究其相互作用可为利什曼病的防治与媒介白蛉的控制提供更多策略。

关键词: 白蛉, 利什曼原虫, 肠道微生物, 肠道功能

Abstract:

Sandflies, as vectors of multiples pathogens, are of significant epidemiological importance, and has been given attention due to their role in transmitting Leishmania. The growth and development of Leishmania is affected by the diverse microbial communities present in the sandfly gut, which also induces differential gene expression in the sandfly gut. This article summarizes the composition of the sandfly gut microbiota and their interactions with Leishmania, and alterations of functional characteristics in the sandfly gut caused by the parasite. Sandflies, Leishmania, gut microbiota, and gene expression form a complex network, and deciphering their interactions may provide more strategies for leishmaniasis management and sandfly vector control.

Key words: Sandfly, Leishmania, Gut microbiota, Gut function

中图分类号:

R531.6

何雅琦, 崔蕾, 方圆, 周正斌, 张仪. 白蛉肠道微生态与利什曼原虫感染相互作用研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(5): 711-717.

HE Yaqi, CUI Lei, FANG Yuan, ZHOU Zhengbin, ZHANG Yi. Progress of researches on interactions between sandfly gut microecology and Leishmania infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(5): 711-717.

图/表 2

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发育类型	发育部位	致病特征	典型虫株	媒介白蛉
上幽门型	中肠→前胃	内脏利什曼病或皮肤利什曼病	杜氏利什曼原虫	白蛉属（旧大陆种）
			婴儿利什曼原虫	罗蛉属（新大陆种）
			热带利什曼原虫
围幽门型	后肠→幽门瓣→中肠→前胃	黏膜型内脏利什曼病	巴西利什曼原虫	罗蛉属（新大陆种）
			圭亚那利什曼原虫
			巴拿马利什曼原虫
下幽门型	后肠	非叮咬传播，不感染人类	蜥蜴利什曼原虫亚属	白蛉属（旧大陆种）

白蛉肠道微生态与利什曼原虫感染相互作用研究进展

Progress of researches on interactions between sandfly gut microecology and Leishmania infection

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